Their victory in , later upheld by the state Supreme Court, resounded across the country, showing that young people have a stake in the issue of climate change, advocates say. Yet, state policies to address the causes of climate change in Montana — home to large coal, oil, and natural gas deposits — haven’t changed in the wake of the case.
On Sept. 17, some of those plaintiffs are scheduled to appear in federal court to request that U.S. District Judge Dana Christensen block a series of President Donald Trump’s executive orders on energy issues. They argue the orders violate their Fifth Amendment rights and will cause nearly 200,000 additional deaths over the next 25 years and lead to more heart, respiratory, and other health problems. They are joined by other plaintiffs ages 7 to 24 from California, Florida, Hawaii, and Oregon, and are backed by the climate-focused nonprofit Our Children’s Trust.
“Trump’s fossil fuel orders are a death sentence for my generation,” Eva Lighthiser, a 19-year-old resident of Livingston, Montana, wrote in the complaint filed on May 29. “I am not suing because I want to, I am suing because I have to. My health, my future and my right to speak the truth are all on the line.”
She added that a warming climate has led to an increase in summer wildfire smoke and contributed to the flooding of the Yellowstone River (a warmer atmosphere holds more precipitation). At the heart of the case, , is the claim that young people are being denied their Fifth Amendment rights under the U.S. Constitution — life, liberty, and the pursuit of happiness — because of the health effects of fossil fuel development and climate change. And they say the Montana Supreme Court’s decision in December to uphold their right to a clean and healthful environment buttresses their claim.

Montana Attorney General Austin Knudsen, a Republican, along with 18 other states and Guam, a U.S. territory, have sided with the Trump administration, filing a motion supporting the government’s request to dismiss the case. They argue the plaintiffs do not have standing to file the lawsuit, and that there is no constitutional right to a specific energy policy. “The state of Montana has an interest in this case because it will directly impact the business done in the energy sector within its borders,” Knudsen argued in his motion.
A hearing on the motion to dismiss, as well as the plaintiffs’ call for a stay of the executive orders, is scheduled for next week in federal court in Missoula.
Olivia Vesovich, 21, one of the plaintiffs, who is in her senior year at the University of Montana in Missoula, told ºÚÁϳԹÏÍø News she struggles with severe spring pollen allergies, which are exacerbated by climate warming and will likely worsen.
“My eyes were swollen shut every single day, every single night,” Vesovich said. “When I wake up in the morning, I couldn’t open my eyes for 10 minutes. It’s not fun at all, and it’s exacerbated by climate change and by the fossil fuel industry.”
She also has exercise-induced asthma as well as feelings of suffocation from the smoke-filled skies during wildfire season — of which are magnified by climate change. And Trump’s executive orders are already being implemented and causing harm, Vesovich said.
“We are making an argument that Olivia’s state constitutional right to a safe climate system should also be protected under the federal Fifth Amendment as part of her liberty right,” said Andrea Rodgers, a senior attorney for Our Children’s Trust.
Our Children’s Trust was also behind the climate change case Juliana v. the United States, filed in 2015 by 21 young plaintiffs who argued their rights had been violated. In 2024, the 9th U.S. Circuit Court of Appeals to dismiss the case, ruling that the courts were not the appropriate venue for climate policy.
They believe the victory in Held v. Montana gives American youth more standing this time. If they prevail, the result would be more far-reaching than the Montana case, creating a national precedent.

The plaintiffs are asking the court to declare Trump’s three related executive orders — “,” “,” and “” — unconstitutional and to block their implementation. They also claim that Trump has overstepped his authority by attempting to undo laws such as the Clean Air Act. A coalition of 14 states’ attorneys general has also filed a lawsuit against the order that declares an energy emergency.
Trump came into office in January sources and to back off efforts to usher in an era of renewable energy, which he claims are not viable. He has also rolling back environmental regulations. “We are driving a dagger into the heart of the climate change religion to drive down the cost of living for American families, unleash American energy, bring auto jobs back to the U.S., and more,” Environmental Protection Agency Administrator Lee Zeldin said in a March news release.
In July, the EPA proposed repealing its 2009 “” that concluded climate-warming gases “endanger both the public health and the public welfare of current and future generations.”
The finding established that greenhouse gases are a pollutant and create adverse effects, such as extreme weather and risks to human health and ecosystems. And it created a foundation to regulate automobiles and the energy sector to address climate change.
Zeldin said that eliminating the rule
Unleashing fossil fuels will come with costs, as well. The health effects of a warming world are thoroughly established , said Kristie Ebi, a University of Washington professor of global health and an expert in the health risks of climate variability. Mosquito-borne diseases such as dengue, chikungunya, and malaria are spreading, and flooding, droughts, and wildfire, exacerbated by climate change, pose threats. And research has shown an increase in deaths.
“There’s a long list of adverse health outcomes” from a warming world, she said. “The data are clear.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/courts/climate-activists-lawsuits-trump-energy-policies-fossil-fuels-violate-rights/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=2080061&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>At the top of the list of worries is a chemical called 6PPD, which is added to rubber tires to help them last longer. When tires wear on pavement, 6PPD is released. It reacts with ozone to become a different chemical, 6PPD-q, which can be extremely toxic — so much so that it has been linked to repeated fish kills in Washington state.
The trouble with tires doesn’t stop there. Tires are made primarily of natural rubber and synthetic rubber, but they contain hundreds of other ingredients, often including steel and heavy metals such as copper, lead, cadmium, and zinc.
As car tires wear, the rubber disappears in particles, both bits that can be seen with the naked eye and microparticles. Testing by a British company, Emissions Analytics, found that a car’s tires emit 1 trillion ultrafine particles per kilometer driven — from 5 to 9 pounds of rubber per internal combustion car per year.
And what’s in those particles is a mystery, because tire ingredients are proprietary.
“You’ve got a chemical cocktail in these tires that no one really understands and is kept highly confidential by the tire manufacturers,” said Nick Molden, CEO of Emissions Analytics. “We struggle to think of another consumer product that is so prevalent in the world and used by virtually everyone, where there is so little known of what is in them.”
Regulators have only begun to address the toxic tire problem, though there has been some action on 6PPD.
The chemical was identified by a team of researchers, led by scientists at Washington State University and the University of Washington, who were trying to determine why coho salmon returning to Seattle-area creeks to spawn were dying in large numbers.
Working for the Washington Stormwater Center, the scientists tested some 2,000 substances to determine which one was causing the die-offs, and in 2020 they announced they’d found the culprit: 6PPD.
The Yurok Tribe in Northern California, along with two other West Coast Native American tribes, have petitioned the Environmental Protection Agency to prohibit the chemical. The EPA said it is considering new rules governing the chemical. “We could not sit idle while 6PPD kills the fish that sustain us,” said Joseph L. James, chairman of the Yurok Tribe, in a statement. “This lethal toxin has no place in any salmon-bearing watershed.”
California has begun taking steps to regulate the chemical, last year classifying tires containing it as a “priority product,” which requires manufacturers to search for and test substitutes.
“6PPD plays a crucial role in the safety of tires on California’s roads and, currently, there are no widely available safer alternatives,” said Karl Palmer, a deputy director at the state’s Department of Toxic Substances Control. “For this reason, our framework is ideally suited for identifying alternatives to 6PPD that ensure the continued safety of tires on California’s roads while protecting California’s fish populations and the communities that rely on them.”
The U.S. Tire Manufacturers Association says it has mobilized a consortium of 16 tire manufacturers to carry out an analysis of alternatives. Anne Forristall Luke, USTMA president and CEO, said it “will yield the most effective and exhaustive review possible of whether a safer alternative to 6PPD in tires currently exists.”
Molden, however, said there is a catch. “If they don’t investigate, they aren’t allowed to sell in the state of California,” he said. “If they investigate and don’t find an alternative, they can go on selling. They don’t have to find a substitute. And today there is no alternative to 6PPD.”
California is also studying a request by the California Stormwater Quality Association to classify tires containing zinc, a heavy metal, as a priority product, requiring manufacturers to search for an alternative. Zinc is used in the vulcanization process to increase the strength of the rubber.
When it comes to tire particles, though, there hasn’t been any action, even as the problem worsens with the proliferation of electric cars. Because of their quicker acceleration and greater torque, electric vehicles wear out tires faster and emit an estimated 20% more tire particles than the average gas-powered car.
A in Southern California found tire and brake emissions in Anaheim accounted for 30% of PM2.5, a small-particulate air pollutant, while exhaust emissions accounted for 19%. Tests by Emissions Analytics have found that tires produce up to 2,000 times as much particle pollution by mass as tailpipes.
These particles end up in water and air and are often ingested. Ultrafine particles, even smaller than PM2.5, are also emitted by tires and can be inhaled and travel directly to the brain. suggests tire microparticles should be classified as a pollutant of “high concern.”
In a , researchers at Imperial College London said the particles could affect the heart, lungs, and reproductive organs and cause cancer.
People who live or work along roadways, often low-income, are exposed to more of the toxic substances.
Tires are also a major source of microplastics. of microplastics entering the ocean come from the synthetic rubber in tires, according to a report from the Pew Charitable Trusts and the British company Systemiq.
And there are still a great many unknowns in tire emissions, which can be especially complex to analyze because heat and pressure can transform tire ingredients into other compounds.
One outstanding research question is whether 6PPD-q affects people, and what health problems, if any, it could cause. A published in Environmental Science & Technology Letters found high levels of the chemical in urine samples from a region of South China, with levels highest in pregnant women.
The discovery of 6PPD-q, Molden said, has sparked fresh interest in the health and environmental impacts of tires, and he expects an abundance of new research in the coming years. “The jigsaw pieces are coming together,” he said. “But it’s a thousand-piece jigsaw, not a 200-piece jigsaw.”
This article was produced by ºÚÁϳԹÏÍø News, which publishes , an editorially independent service of the .Ìý
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/rural-health/tire-toxicity-salmon-die-offs-research-6ppd/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1843991&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>The BCG (Bacille Calmette-Guérin) vaccine, created in 1921, remains the sole TB vaccine. While it is 40% to 80% effective in young children, its efficacy is very low in adolescents and adults, leading to a worldwide push to create a more powerful vaccine.
One effort is underway at the University of Montana Center for Translational Medicine. The center specializes in improving and creating vaccines by adding what are called novel adjuvants. An adjuvant is a substance included in the vaccine, such as fat molecules or aluminum salts, that enhances the immune response, and novel adjuvants are those that have not yet been used in humans. Scientists are finding that adjuvants make for stronger, more precise, and more durable immunity than antigens, which create antibodies, would alone.
Eliciting specific responses from the immune system and deepening and broadening the response with adjuvants is known as precision vaccination. “It’s not one-size-fits-all,” said Ofer Levy, a professor of pediatrics at Harvard University and the head of the Precision Vaccines Program at Boston Children’s Hospital. “A vaccine might work differently in a newborn versus an older adult and a middle-aged person.”
The ultimate precision vaccine, said Levy, would be lifelong protection from a disease with one jab. “A single-shot protection against influenza or a single-shot protection against covid, that would be the holy grail,” Levy said.
Jay Evans, the director of the University of Montana center and the chief scientific and strategy officer and a co-founder of Inimmune, a privately held biotechnology company in Missoula, said his team has been working on a TB vaccine for 15 years. The private-public partnership is developing vaccines and trying to improve existing vaccines, and he said it’s still five years off before the TB vaccine might be distributed widely.
It has not gone unnoticed at the center that this state-of-the-art vaccine research and production is located in a state that passed one of the nation’s most extreme anti-vaccination laws during the pandemic in 2021. The law prohibits businesses and governments from discriminating against people who aren’t vaccinated against covid-19 or other diseases, effectively banning both public and private employers from requiring workers to get vaccinated against covid or any other disease. that the law cannot be enforced in health care settings, such as hospitals and doctors’ offices.
In mid-March, the Bill & Melinda Gates Medical Research Institute announced it had begun the third and final phase of clinical trials for the new vaccine in seven countries. The trials should take about five years to complete. Research and production are being done in several places, including at a manufacturing facility in Hamilton owned by GSK, a giant pharmaceutical company.
Known as the forgotten pandemic, TB kills up to 1.6 million people a year, mostly in impoverished areas in Asia and Africa, despite its being both preventable and treatable. The U.S. has seen an increase in tuberculosis over the past decade, especially with the influx of migrants, and the number of cases rose by 16% from 2022 to 2023. Tuberculosis is the leading cause of death among people living with HIV, whose risk of contracting a TB infection is 20 times as great as people without HIV.
“TB is a complex pathogen that has been with human beings for ages,” said Alemnew Dagnew, who heads the program for the new vaccine for the Gates Medical Research Institute. “Because it has been with human beings for many years, it has evolved and has a mechanism to escape the immune system. And the immunology of TB is not fully understood.”
The University of Montana Center for Translational Medicine and Inimmune together have 80 employees who specialize in researching a range of adjuvants to understand the specifics of immune responses to different substances. “You have to tailor it like tools in a toolbox towards the pathogen you are vaccinating against,” Evans said. “We have a whole library of adjuvant molecules and formulations.”
Vaccines are made more precise largely by using adjuvants. There are three basic types of natural adjuvants: aluminum salts; squalene, which is made from shark liver; and some kinds of saponins, which are fat molecules. It’s not fully understood how they stimulate the immune system. The center in Missoula has also created and patented a synthetic adjuvant, UM-1098, that drives a specific type of immune response and will be added to new vaccines.
One of the most promising molecules being used to juice up the immune system response to vaccines is a saponin molecule from the bark of the quillay tree, gathered in Chile from trees at least 10 years old. Such molecules were used by Novavax in its covid vaccine and by GSK in its widely used shingles vaccine, Shingrix. These molecules are also a key component in the new tuberculosis vaccine, known as the M72 vaccine.
But there is room for improvement.
“The vaccine shows 50% efficacy, which doesn’t sound like much, but basically there is no effective vaccine currently, so 50% is better than what’s out there,” Evans said. “We’re looking to take what we learned from that vaccine development with additional adjuvants to try and make it even better and move 50% to 80% or more.”
By contrast, measles vaccines are 95% effective.
According to Medscape, around 15 vaccine candidates are being developed to replace the BCG vaccine, and three of them are in phase 3 clinical trials.
One approach Evans’ center is researching to improve the new vaccine’s efficacy is taking a piece of the bacterium that causes TB, synthesizing it, and combining it with the adjuvant QS-21, made from the quillay tree. “It stimulates the immune system in a way that is specific to TB and it drives an immune response that is even closer to what we get from natural infections,” Evans said.
The University of Montana center is researching the treatment of several problems not commonly thought of as treatable with vaccines. They are entering the first phase of clinical trials for a vaccine for allergies, for instance, and first-phase trials for a cancer vaccine. And later this year, clinical trials will begin for vaccines to block the effects of opioids like heroin and fentanyl. The University of Montana received the largest grant in its history, $33 million, for anti-opioid vaccine research. It works by creating an antibody that binds with the drug in the bloodstream, which keeps it from entering the brain and creating the high.
For now, though, the eyes of health care experts around the world are on the trials for the new TB vaccines, which, if they are successful, could help save countless lives in the world’s poorest places.
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/new-better-tuberculosis-tb-vaccine-montana/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1840711&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>These hunters, however, are not just on the front lines of an American tradition. Infectious disease researchers say they are also on the front lines of what could be a serious threat to public health: chronic wasting disease.
The neurological disease, which is contagious, rapidly spreading, and always fatal, is caused by misfolded proteins called prions. It currently is known to infect only members of the cervid family — elk, deer, reindeer, caribou, and moose.
Animal disease scientists are alarmed about the rapid spread of CWD in deer. shows that the barrier to a spillover into humans is less formidable than previously believed and that the prions causing the disease may be evolving to become more able to infect humans.
A response to the threat is ramping up. In 2023, a coalition of researchers began “working on a major initiative, bringing together 68 different global experts on various aspects of CWD to really look at what are the challenges ahead should we see a spillover into humans and food production,” said , an expert in infectious disease at the University of Minnesota and a leading authority on CWD.
“The bottom-line message is we are quite unprepared,” Osterholm said. “If we saw a spillover right now, we would be in free fall. There are no contingency plans for what to do or how to follow up.”
The team of experts is planning for a potential outbreak, focusing on public health surveillance, lab capacity, prion disease diagnostics, surveillance of livestock and wildlife, risk communication, and education and outreach.
Despite the concern, tens of thousands of infected animals have been eaten by people in recent years, yet there have been no known human cases of the disease.
Many hunters have wrestled with how seriously to take the threat of CWD. “The predominant opinion I encounter is that no human being has gotten this disease,” said Steve Rinella, a writer and the founder of MeatEater, a media and lifestyle company focused on hunting and cooking wild game.
They think, “I am not going to worry about it because it hasn’t jumped the species barrier,” Rinella said. “That would change dramatically if a hunter got CWD.”
Other prion diseases, such as bovine spongiform encephalopathy, also known as mad cow disease, and Creutzfeldt-Jakob disease, have affected humans. Mad cow claimed the lives of , mostly in the United Kingdom and France. Some experts believe Parkinson’s and Alzheimer’s also may be caused by prions.
First discovered in Colorado in captive deer in 1967, CWD has since spread widely. It has been found in animals in at least 32 states, four Canadian provinces, and four other foreign countries. It was for the first time in Yellowstone National Park.
Prions behave very differently than viruses and bacteria and are virtually impossible to eradicate. Matthew Dunfee, director of the Chronic Wasting Disease Alliance, said experts call it a “disease from outer space.”
Symptoms are gruesome. The brain deteriorates to a spongy consistency. Sometimes nicknamed “zombie deer disease,” the condition makes infected animals stumble, drool, and stare blankly before they die. There is no treatment or vaccine. And it is extremely difficult to eradicate, whether with disinfectants or with high heat — it even survives autoclaving, or medical sterilization.
Cooking doesn’t kill prions, said Osterholm. Unfortunately, he said, “cooking concentrates the prions. It makes it even more likely” people will consume them, he said.
Though CWD is not known to have passed to humans or domestic animals, experts are very concerned about both possibilities, which Osterholm’s group just received more than $1.5 million in funding to study. CWD can infect more parts of an animal’s body than other prion diseases like mad cow, which could make it more likely to spread to people who eat venison — if it can jump to humans.
Researchers estimate that between 7,000 and 15,000 infected animals are unknowingly consumed by hunter families annually, a number that increases every year as the disease spreads across the continent. While testing of wild game for CWD is available, it’s cumbersome and the tests are not widely used in many places.
A major problem with determining whether CWD has affected humans is that it has a long latency. People who consume prions may not contract the resulting disease until many years later — so, if someone fell sick, there might not be an apparent connection to having eaten deer.
Prions are extremely persistent in the environment. They can remain in the ground for many years and even be taken up by plants.
Because the most likely route for spillover is through people who eat venison, quick testing of deer and other cervid carcasses is where prevention is focused. Right now, a hunter may drive a deer to a check station and have a lymph node sample sent to a lab. It can be a week or more before results come in, so most hunters skip it.
Montana, for example, is famous for its deer hunting. CWD was first detected in the wild there in 2017 and now has spread across much of the state. Despite warnings and free testing, Montana wildlife officials have not seen much concern among hunters. “We have not seen a decrease in deer hunting because of this,” said Brian Wakeling, game management bureau chief for the Montana Department of Fish, Wildlife & Parks. In 2022 Montana hunters killed nearly 88,000 deer. Just 5,941 samples were taken, and 253 of those tested positive.
Experts believe a rapid test would greatly increase the number of animals tested and help prevent spillover.
Because of the importance of deer to Indigenous people, several tribal nations in Minnesota are working with experts at the University of Minnesota to come up with ways to monitor and manage the disease. “The threat and potential for the spread of CWD on any of our three reservations has the ability to negatively impact Ojibwe culture and traditions of deer hunting providing venison for our membership,” said , a tribal biologist for the White Earth Nation, in a statement announcing the program. (The other groups referenced are the Leech Lake Band of Ojibwe and Red Lake Band of Chippewa.) “Tribes must be ready with a plan to manage and mitigate the effects of CWD … to ensure that the time-honored and culturally significant practice of harvesting deer is maintained for future generations.”
is an assistant professor in the College of Veterinary Medicine at the University of Minnesota and co-director of the . The center was formed to study numerous aspects of prions as part of the push to get ahead of possible spillover. “Our mission is to learn everything we can about not just CWD but other prionlike diseases, including Parkinson’s and Alzheimer’s disease,” he said. “We are studying the biology and ecology” of the misfolded protein, he said. “How do prions move within the environment? How can we help mitigate risk and improve animal health and welfare?”
Part of that mission is new technology to make testing faster and easier. Researchers have developed a way for hunters to do their own testing, though it can take weeks for results. There’s hope for, within the next two years, a test that will reduce the wait time to three to four hours.
“With all the doom and gloom around CWD, we have real solutions that can help us fight this disease in new ways,” said Larsen. “There’s some optimism.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/chronic-wasting-disease-deer-cervids-hunting-prions/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1803547&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Six-foot-tall corn plants tower over large green squash and black-and-yellow sunflowers. Around the perimeter, stalks of sweetgrass grow.
The seeds for some of these plants grew for millennia in Native Americans’ gardens along the upper Missouri River. It’s one of several Native American ancestral gardens growing in the Bozeman area, totaling about an acre. Though small, the garden is part of a larger, multifaceted effort around the country to promote “food sovereignty” for reservations and tribal members off reservation, and to reclaim aspects of Native American food and culture that flourished in North America for thousands of years before the arrival of European settlers. Restoring bison to reservations, developing community food gardens with ancestral seeds, understanding and collecting wild fruits and vegetables, and learning how to cook tasty meals with traditional ingredients are all part of the movement.
“We are learning to care for plant knowledge, growing Indigenous gardens, cultivating ancestral seeds — really old seeds from our relatives the Mandan, Hidatsa, and Arikara: corn, beans, squash, and sunflowers,” said Jill Falcon Ramaker, an assistant professor of community nutrition and sustainable food systems at Montana State. She is a member of the Turtle Mountain Band of Anishinaabe.
“A lot of what we are doing here at the university is cultural knowledge regeneration,” she said.
But it also has a very practical application: to provide healthier, cheaper, and more reliable food supplies for reservations, which are often a long way from supermarkets, and where processed foods have helped produce an epidemic of diabetes and heart disease.

Many reservations are food deserts where prices are high and processed food is often easier to come by than fresh food. , a 2020 paper funded by the U.S. Department of Agriculture, found that the median cost in the state of a collection of items typically purchased at a grocery store is 23% higher on a reservation than off.
“With food sovereignty we are looking at the ability to put that healthy food and ancestral foods which we used to survive for thousands of years, putting those foods back on the table,” Ramaker said. What that means exactly can vary by region, depending on the traditional food sources, from wild rice in the Midwest to salmon on the Pacific coast.
Central to the effort, especially in Montana, are bison, also referred to as buffalo. In 2014, 13 Native nations from eight reservations in the U.S. and Canada came together to sign the Buffalo Treaty, an agreement to return bison to 6.3 million acres that sought “to welcome BUFFALO to once again live among us as CREATOR intended by doing everything within our means so WE and BUFFALO will once again live together to nurture each other culturally and spiritually.”

Nearly a decade later, dozens of tribes have buffalo herds, including all seven reservations in Montana.
The buffalo-centered food system was a success for thousands of years, according to Ramaker, who directs both the regional program, known as the Buffalo Nations Food Systems Initiative — a collaboration with the Native American Studies Department and College of Education, Health and Human Development at Montana State — and the Montana-specific effort, known as the Montana Indigenous Food Sovereignty Initiative. It wasn’t a hand-to-mouth existence, she wrote in an article for Montana State, but a “knowledge of a vast landscape, including an intimate understanding of animals, plants, season, and climate, passed down for millennia and retained as a matter of life and death.”
With bison meat at the center of the efforts, the BNFSI is working to bring other foods from the northern Plains Native American diet in line with modern palates.
The BNFSI has received a $5 million grant from the U.S. Department of Agriculture to carry out that work, in partnership with Nueta Hidatsa Sahnish College in New Town, North Dakota.

Life on reservations is partly to blame for many Native people eating processed foods, Ramaker said. Food aid from the federal government, known as the Commodity Supplemental Food Program, has long been shipped to reservations in the form of boxes full of packaged foods. “We were forced onto the reservations, where there was replacement food sent by the government — white flour, white sugar, canned meat, salt, and baking powder,” she said.
processed foods contribute to chronic inflammation, which in turn leads to heart disease, cancer, and diabetes, which occurs at in Native Americans as it does in white people.
Studies show that people’s mental and physical health declines when they consume a processed food diet. “In the last decade there’s a growing amount of research on the impact of good nutrition on suicide ideation, attempts, and completion,” said KayAnn Miller, co-executive director of the Montana Partnership to End Childhood Hunger in Bozeman, who is also involved with the BNFSI.

All Native American reservations in Montana now have community gardens, and there are at least eight gardens on the Flathead Reservation north of Missoula, home to the Confederated Salish and Kootenai Tribes. The tribe is teaching members to raise vegetables, some of them made into soup that is delivered to tribal elders. This year members grew 5 tons of produce to be given away.
Ancestral seeds are part of the effort. Each year the BNFSI sends out 200 packets of seeds for ancestral crops to Indigenous people in Montana.
Creating foods that appeal to contemporary tastes is critical to the project. The BNFSI is working with Sean Sherman, the “Sioux Chef,” to turn corn, meat, and other Native foods into appealing dishes.
Sherman founded the award-winning Owamni restaurant in Minneapolis and in 2020 opened the Indigenous Food Lab, through his nonprofit, North American Traditional Indigenous Food Systems. The lab, in downtown Minneapolis, is also a restaurant and an education and training center that creates dishes using only Indigenous foods from across the country — no dairy, cane sugar, wheat flour, beef, chicken, or other ingredients from what he calls the colonizers.
“We’re not cooking like it’s 1491,” Sherman said last year on the NPR program “Fresh Air,” referring to the period before European colonization. “We’re not a museum piece or something like that. We’re trying to evolve the food into the future, using as much of the knowledge from our ancestors that we can understand and just applying it to the modern world.” Among his signature dishes are bison pot roast with hominy and roast turkey with a berry-mint sauce and black walnuts.
The Bozeman-based nonprofit HRDC built a $29 million building with a state-of-the-art kitchen that will house the country’s second Indigenous food lab, Ramaker said. It will open next year and expand the ongoing work creating recipes, holding cooking workshops, and preparing cooking videos.

Angelina Toineeta, who is Crow, is studying the BNFSI at Montana State as part of her major in agriculture. “Growing these gardens really stuck out to me,” she said. “Native American agriculture is something we’ve lost over the years, and I want to help bring that back.”
This <a target="_blank" href="/rural-health/native-indigenous-food-sovereignty-movement-bison-sioux-chef/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1763569&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>During her time in the Florida Legislature, Cruz had supported a new law allowing the use of treated wastewater in local water systems. But many Tampa residents were staunchly opposed to a plan by their water utility to do just that, and Cruz was forced to backtrack, with her spokesperson asserting she had never favored the type of complete water reuse known as “toilet to tap.” She lost anyway, and the water plan has been canceled.
Tampa’s showdown may be a harbinger of things to come as climate change and drought cause water shortages in many parts of the country. With few alternatives for expanding supply, cities and states are rapidly adding recycled water to their portfolios and expanding the ways in which it can be used. Researchers say it’s safe — and that it’s essential to move past the 20th century notion that wastewater must stay flushed.
“There is no reason to only use water once,” said Peter Fiske, director of the National Alliance for Water Innovation at the Lawrence Berkeley National Laboratory. “We’ve got to be more clever with the water we’ve got.”
But proponents are still fighting an uphill battle to overcome the “yuck” factor. A found that reused water is not only safe but that it’s actually cleaner than conventionally sourced water — yet acceptance is “hindered by perceptions of poor water quality and potential health threats.”
Several projects were canceled in California in the 1990s because of such worries. In San Gabriel, Miller Brewing Company opposed a water reclamation project when people started joking about “beer aged in porcelain.”
“You have to have a lot of education in a community to say why [recycled water] is needed” and what experts are doing to ensure the safety of the water, said Noelle George, the Texas managing director for the trade association WateReuse.
Many forms of water reuse have long been routine. Water from yard sprinklers, for example, soaks into the groundwater. Or, if it is processed in a treatment plant, it goes into a river or lake, where it’s used again. Municipalities and others often treat a form of wastewater known as gray water to use for irrigation.
But in the world of water reuse, the gold standard is known as direct potable reuse — cleaning wastewater, including sewage, to drinking water standards.
With DPR systems, the water from showers, sinks, and toilets first goes to a conventional treatment plant, where it is disinfected with chemicals and aeration. Then it gets a second scrubbing in a multistage process that first uses a bioreactor to break down nitrogen compounds, then employs microfiltration to clean out particles and reverse osmosis to remove viruses, bacteria, and salts. Finally, hydrogen peroxide is added and the water goes through an ultraviolet light processing, which is supposed to kill any contaminants that are left.
Experts say the water that emerges at the end of this process is so clean it has no taste, and that minerals must be added to give the water flavor. It’s also free of a little-known health hazard; chlorine, often used to disinfect conventional water, can react with organic material in the water to create chloroform, exposure to which can cause negative health effects.
Big Spring, Texas, is the only place in the country with a DPR municipal water system, in which all wastewater is treated and sent back to the tap. Another notable DPR system is the Changi Water Reclamation Plant in Singapore, which cleans 237 million gallons each day.
In Tampa, intense opposition focused on the high cost of the water treatment and the possible presence of pharmaceuticals, hormones, and so-called forever chemicals, .
“We have never thought that it was necessary to drink wastewater,” said Gary Gibbons, the vice chair of the Tampa Bay Sierra Club, in September 2022. He said the project, which the city referred to by the acronym PURE, would result in contaminants in the drinking water and the groundwater aquifer.
Experts reject these concerns as uninformed and say properly treated wastewater is safer than a lot of conventional drinking water sources.
“I would almost rather have an advanced treatment plant of the type used for potable water recycling than water that comes from a river that has several cities and farms and industries upstream that are discharging into it,” said David L. Sedlak, an expert on potable reuse at the University of California-Berkeley.
With higher temperatures and long-term pressure on water sources including aquifers and mountain snowpacks, a lot more water reuse is coming.
In Texas, the state permits DPR plants on a case-by-case basis, and the city of El Paso is building one that’s slated to be online by 2026. Colorado last year DPR. In California, regulations spelling out the approach to DPR by the end of this year, with some cities setting goals of recycling all water by 2035. Florida and Arizona are also moving to expand direct potable reuse.
There’s also a lot of activity around what’s known as indirect potable reuse. Orange County, California, has the world’s largest IPR facility, which cleans 130 million gallons of water a day to irrigation standards, passes it through advanced purification, and finally injects it into groundwater, which serves as an environmental buffer. The water is then piped to all municipal users.
San Francisco is pioneering another approach. Since 2015, the San Francisco Public Utilities Commission, which operates the dams, reservoirs, and aqueducts that deliver water from the Sierra Nevada to the city, has required all buildings over 100,000 square feet be equipped for recycling gray water. The downtown Salesforce Tower has its own recycling plant: Sinks, laundry machines, and showers drain into the basement recycling system, and the water is then reused for flushing toilets and irrigation, saving about 30,000 gallons a day.
“We don’t need to flush toilets with drinking water,” said Fiske, noting that toilets make up about 30% of all water use.
San Francisco water officials are studying the feasibility and safety of cleaning all wastewater to potable standards at the building level. The headquarters of the water utility has a blackwater system called the Living Machine that uses engineered wetlands in the sidewalks around the building to treat wastewater, cutting water use by two-thirds. (Blackwater systems recycle water from toilets; gray water systems reuse water from all other drains.)
Some experts see a day when buildings will not have to be hooked up to external sewer and water systems at all, with advanced recycling systems augmented by rainwater. For the moment, though, educational campaigns are still needed to bring recycled water into the mainstream.
Epic Cleantec, which created a recycling system for a new San Francisco apartment tower, thought beer might help. The company last year teamed up with a local brewery to produce beer from recycled water. The Epic OneWater Brew by Devil’s Canyon Brewing isn’t sold; rather, it’s a demonstration product, given away and served at events.
While people might not want to drink recycled water, they will usually try the beer.
“We made beer out of recycled water, because we’re trying to change the conversation,” said Aaron Tartakovsky, CEO of Epic Cleantec. “We’re fundamentally trying to help people rethink how our communities handle water.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/health-industry/water-direct-potable-reuse-expands-yuk-factor/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
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In the 1990s, residents of Mexico City noticed their dogs acting strangely — some didn’t recognize their owners, and the animals’ sleep patterns had changed.
At the time, the sprawling, mountain-ringed city of more than 15 million people was known as the most polluted in the world, with a thick, constant haze of fossil fuel pollution trapped by thermal inversions.
In 2002, toxicologist and neuropathologist Lilian Calderón-Garcidueñas, who is affiliated with both Universidad del Valle de México in Mexico City and the University of Montana, examined brain tissue from 40 dogs that had lived in the city and 40 others from a nearby rural area with cleaner air. She discovered the brains of the city dogs showed signs of neurodegeneration while the rural dogs had far healthier brains.
Calderón-Garcidueñas went on to of 203 human residents of Mexico City, only one of which did not show signs of neurodegeneration. That led to the conclusion that chronic exposure to air pollution can negatively affect people’s olfactory systems at a young age and may make them more susceptible to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
The pollutant that plays the “big role” is particulate matter, said Calderón-Garcidueñas. “Not the big ones, but the tiny ones that can cross barriers. We can detect nanoparticles inside neurons, inside glial cells, inside epithelial cells. We also see things that shouldn’t be there at all — titanium, iron, and copper.”
The work the Mexican scientist is doing is feeding a burgeoning body of evidence that shows breathing polluted air not only causes heart and lung damage but also neurodegeneration and mental health problems.
It’s that air pollution takes a serious toll on the human body, affecting almost every organ. Asthma, cardiovascular disease, cancer, premature death, and stroke are among a long list of problems that can be caused by exposure to air pollution, which, according to the World Health Organization, sits atop the list of health threats globally, causing 7 million deaths a year. Children and infants are especially susceptible.
Sussing out the impact of air pollution on the brain has been more difficult than for other organs because of its inaccessibility, so it has not been researched as thoroughly, according to researchers. Whether air pollution may cause or contribute to Alzheimer’s or Parkinson’s is not settled science. But Calderón-Garcidueñas’ work is at the leading edge of showing that air pollution goes directly into the brain through the air we breathe, and has serious impacts.
Some psychotherapists report seeing patients with symptoms stemming from air pollution. Not only does the pollution appear to cause symptoms or make them worse; it also takes away forms of relief.
“If we exercise and spend time in nature we become extra resilient,” said Kristen Greenwald, an environmental social worker and adjunct professor at the University of Denver. “A lot of folks do that outside. That’s their coping mechanism; it’s soothing to the nervous system.”
On polluted days a lot of her clients “can’t go outside without feeling they are making themselves more sick or distressed.”
Megan Herting, who researches air pollution’s impact on the brain at the University of Southern California, said environmental factors should be incorporated in doctors’ assessments these days, especially in places like Southern California and Colorado’s Front Range, where high levels of air pollution are a chronic problem.
“When I go into a medical clinic, they rarely ask me where I live and what is my home environment like,” she said. “Where are we living, what we are exposed to, is important in thinking about prevention and treatment.”
In the last two decades, with new technologies, research on air pollution and its impact on the human nervous system has grown by leaps and bounds.
Research shows tiny particles as they are breathed in through the nose and mouth and travel directly into the brain. Fine and ultrafine particles, which come from diesel exhaust, soot, dust, and wildfire smoke, among other sources, often contain metals that hitchhike a ride, worsening their impact.
A changing climate is likely to exacerbate the effects of air pollution on the brain and mental health. Warmer temperatures react with tailpipe emissions from cars to create more ozone than is generated when it’s cooler. And more and larger forest fires are expected to mean more days of smoky skies.
Ozone has been , decline in cerebral plasticity, the death of neurons, and learning and memory impairment. Ozone levels are extremely high in Los Angeles and the mountain valleys of the West, including the Front Range of Colorado, Phoenix, and Salt Lake City.
Air pollution also causes damage from chronic inflammation. As air pollution particles enter the brain, they are mistaken for germs and attacked by microglia, a component of the brain’s immune system, and they stay activated.
“Your body doesn’t like to be exposed to air pollution and it produces an inflammatory response,” said Patrick Ryan, a researcher at Cincinnati Children’s Hospital, in an email. “Your brain doesn’t like it either. There’s more than 10 years of toxicological science and epidemiologic studies that show air pollution causes neuro-inflammation.”
Much of the current research focuses on how pollution causes mental health problems.
Damage to the brain is especially pernicious because it is the master control panel for the body, and pollution damage can cause a range of neuropsychiatric disorders. A primary focus of research these days is how pollution-caused damage affects areas of the brain that regulate emotions — such as the amygdala, prefrontal cortex, and hippocampus. The amygdala, for example, governs the processing of fearful experiences, and its impairment can cause anxiety and depression. In one recent review, looking at both physical and functional changes to areas of the brain that regulate emotion showed an impact from air pollution.
published in February in JAMA Psychiatry, by researchers from the universities of Oxford and Peking and Imperial College London, tracked the incidence of anxiety and depression in nearly 400,000 adults in the United Kingdom over a median length of 11 years and found that long-term exposure even to low levels of a combination of air pollutants — particulate matter, nitrogen dioxide, and nitric oxide — increased the occurrence of depression and anxiety.
Another recent study, by Erika Manczak at the University of Denver, found adolescents exposed to ozone predicted “for steeper increases in depressive symptoms across adolescent development.”
But the epidemiological research has shortcomings because of confounding factors that are difficult to account for. Some people may be genetically predisposed to susceptibility and others not. Some may experience chronic stress or be very young or very old, which can increase their susceptibility. People who reside near a lot of green space, which reduces anxiety, may be less susceptible.
“Folks living in areas where there is greater exposure to pollutants tend to be areas under-resourced in many ways and grappling with a lot of systemic problems. There are bigger reports of stress and depression and anxiety,” said Manczak. “Given that those areas have been marginalized for a lot of reasons, it’s a little hard to say this is due to air pollution exposure.”
The best way to tell for sure would be to conduct clinical trials, but that comes with ethical problems. “We can’t randomly expose kids to air pollution,” Ryan said.
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/mental-health/air-pollution-mental-health-impact-research-depression-anxiety/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1674935&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Bats worldwide are primary vectors for virus transmission from animals to humans. Those viruses often are harmless to bats but can be deadly to humans. Horseshoe bats in China, for example, are cited as a likely cause of the covid-19 outbreak. And researchers believe pressure put on bats by climate change and encroachment from human development have increased the frequency of viruses jumping from bats to people, causing what are known as zoonotic diseases.
“Spillover events are the result of a cascade of stressors — bat habitat is cleared, climate becomes more extreme, bats move into human areas to find food,” said Raina Plowright, a disease ecologist and co-author of a recent paper in the and another in on the role of ecological changes in disease.
That’s why Montana State University immunologist Agnieszka Rynda-Apple plans to bring the Jamaican fruit bats to Bozeman this winter to start a breeding colony and accelerate her lab’s work as part of a team of 70 researchers in seven countries. The group, called BatOneHealth — founded by Plowright — hopes to find ways to predict where the next deadly virus might make the leap from bats to people.
“We’re collaborating on the question of why bats are such a fantastic vector,” said Rynda-Apple. “We’re trying to understand what is it about their immune systems that makes them retain the virus, and what is the situation in which they shed the virus.”
To study the role of nutritional stress, researchers create different diets for them, she said, “and infect them with the influenza virus and then study how much virus they are shedding, the length of the viral shedding, and their antiviral response.”
While she and her colleagues have already been doing these kinds of experiments, breeding bats will allow them to expand the research.
It’s a painstaking effort to thoroughly understand how environmental change contributes to nutritional stress and to better predict spillover. “If we can really understand all the pieces of the puzzle, that gives us tools to go back in and think about eco-counter measures that we can put in place that will break the cycle of spillovers,” said Andrew Hoegh, an assistant professor of statistics at MSU who is creating models for possible spillover scenarios.
The small team of researchers at MSU works with a researcher at the National Institutes of Health’s Rocky Mountain Laboratories in Hamilton, Montana.
The recent papers published in Nature and Ecology Letters focus on the Hendra virus in Australia, which is where Plowright was born. Hendra is a respiratory virus that causes flu-like symptoms and spreads from bats to horses, and then can be passed on to people who treat the horses. It is deadly, with a mortality rate of . Of the seven people known to have been infected, four died.
The question that propelled Plowright’s work is why Hendra began to show up in horses and people in the 1990s, even though bats have likely hosted the virus for eons. The research demonstrates that the reason is environmental change.
Plowright began her bat research in 2006. In samples taken from Australian bats called flying foxes, she and her colleagues rarely detected the virus. After Tropical Cyclone Larry off the coast of the Northern Territory wiped out the bats’ food source in 2005-06, hundreds of thousands of the animals simply disappeared. However, they found one small population of weak and starving bats loaded with the Hendra virus. That led Plowright to focus on nutritional stress as a key player in spillover.
She and her collaborators scoured 25 years of data on habitat loss, spillover, and climate and discovered a link between the loss of food sources caused by environmental change and high viral loads in food-stressed bats.
In the year after an climate pattern, with its high temperatures — occurring every few years — many eucalyptus trees don’t produce the flowers with nectar the bats need. And human encroachment on other habitats, from farms to urban development, has eliminated alternative food sources. And so the bats tend to move into urban areas with substandard fig, mango, and other trees, and, stressed, shed virus. When the bats excrete urine and feces, horses inhale it while sniffing the ground.
The researchers hope their work with Hendra-infected bats will illustrate a universal principle: how the destruction and alteration of nature can increase the likelihood that deadly pathogens will spill over from wild animals to humans.
The three most likely sources of spillover are bats, mammals, and arthropods, especially ticks. Some that infect humans come from animals, and about two-thirds of those come from wild animals.
The idea that deforestation and human encroachment into wild land fuels pandemics is not new. For example, experts believe that HIV, which causes AIDS, first infected humans when people ate chimpanzees in central Africa. A Malaysian outbreak in late 1998 and early 1999 of the bat-borne Nipah virus spread from bats to pigs. The pigs amplified it, and it spread to humans, infecting 276 people and killing 106 in that outbreak. Now emerging is the connection to stress brought on by environmental changes.
One critical piece of this complex puzzle is bat immune systems. The Jamaican fruit bats kept at MSU will help researchers learn more about the effects of nutritional stress on their viral load.
Vincent Munster, chief of the virus ecology unit of Rocky Mountain Laboratories and a member of BatOneHealth, is also looking at different species of bats to better understand the ecology of spillover. “There are 1,400 different bat species and there are very significant differences between bats who harbor coronaviruses and bats who harbor Ebola virus,” said Munster. “And bats who live with hundreds of thousands together versus bats who are relatively solitary.”
Meanwhile, Plowright’s husband, Gary Tabor, is president of the Center for Large Landscape Conservation, a nonprofit that applies ecology of disease research to protect wildlife habitat — in part, to assure that wildlife is adequately nourished and to guard against virus spillover.
“Habitat fragmentation is a planetary health issue that is not being sufficiently addressed, given the world continues to experience unprecedented levels of land clearing,” said Tabor.
As the ability to predict outbreaks improves, other strategies become possible. Models that can predict where the Hendra virus could spill over could lead to vaccination for horses in those areas.
Another possible solution is the set of “eco-counter measures” Hoegh referred to — such as large-scale planting of flowering eucalyptus trees so flying foxes won’t be forced to seek nectar in developed areas.
“Right now, the world is focused on how we can stop the next pandemic,” said Plowright. “Unfortunately, preserving or restoring nature is rarely part of the discussion.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/a-secret-weapon-in-preventing-the-next-pandemic-fruit-bats/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1614995&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>But new Colorado laws aimed at improving air quality along that urban corridor east of the Rocky Mountains aren’t expected to do much to directly reduce ozone, according to experts charged with bringing down the levels. “These are not the magic bullets that will bring us into compliance, but they will be helpful in reducing emissions,” said Michael Silverstein, executive director of the Regional Air Quality Council, the lead air-quality planning organization for nine counties of the Front Range.
In the most recent legislative session, Colorado lawmakers passed three bills aimed at improving air quality: One replaces highly polluting diesel buses with electric buses, another provides funding so residents can access public transportation free of charge for a month during the high-ozone season, and the third creates a system to alert the public to toxic emissions released from industrial sources.
to reclassify nine counties of the Front Range, including Denver, from “serious” violators of federal ozone standards to “severe” violators would bring more significant change, Silverstein said. (The EPA’s begin with “serious” and then move to “severe” and “extreme.”)
But other health experts say neither the federal nor the state actions will be enough to truly safeguard public health.
“At some point, you are just putting band-aids on, and this feels like that,” said James Crooks, an air pollution researcher at National Jewish Health, a Denver hospital that specializes in respiratory disorders. “Better to have the band-aids than not, but it’s not going to solve the problem.”
Ozone is created when chemicals emitted into the atmosphere via vehicle exhaust, oil and gas development, and wildfires are baked by the sun. Ozone pollution that exceeds federal limits is a stubborn problem in Mountain West valleys, especially in Phoenix; Albuquerque, New Mexico; Salt Lake City; and Denver.
The Front Range has one of the worst ozone problems in the country. Last year, health officials in the counties east of the Rocky Mountains issued “ozone action day alerts” on 65 days from May 31 to Aug. 31, peak season for ozone. That’s the highest number since record-keeping began in 2011.
The EPA determined that over the three-year period from 2018 to 2020, average ozone levels over eight hours on the Front Range were 81 parts per billion. The federal limit set in 2008 was 75 ppb, but the current one, set in 2015, is 70 ppb. Under the proposal to change a nine-county area of the Front Range from a “serious” to a “severe” violator, the region would have to meet that standard by 2026.
A final decision on the proposal is expected from the EPA this fall.
“Ground-level ozone remains one of the most challenging public health concerns we face, affecting large numbers of Coloradans and their families,” EPA Regional Administrator KC Becker said in an April news release announcing the proposed change.
Crooks said that 70 ppb is a difficult goal to achieve and that it isn’t low enough to protect public health. Indeed, no level of ozone is safe, he said. “We might be able to muddle through and get to 75,” said Crooks. “But 70 is going to be really hard to do without decarbonization,” which means replacing gas and diesel vehicles with electric vehicles.
One challenge in reducing ozone is trying to control the emission of ozone precursors from myriad sources. Thousands of oil and gas wells are along the Front Range, some in suburban neighborhoods, and their emissions, along with vehicle emissions, are the primary sources of ozone.
Complicating the matter is that one-half to two-thirds of the ozone that plagues the Front Range comes from outside the state, some from as far away as Asia. The background levels of ozone — naturally or human-created ozone that originates from outside the region — can be as high as 60 ppb.
Another problem is the wildfire smoke that blankets the state each summer. And rising temperatures, a result of climate change, are causing more ozone to be produced.
Ground-level ozone is the same chemical as the ozone that is high in the atmosphere, but up there, it provides a crucial shield that protects the Earth from harmful ultraviolet rays.
On the ground, the odorless gas can cause shortness of breath and stinging in the eyes and can trigger asthma attacks. It predisposes people to pulmonary inflammation and coronary damage. Globally, were caused by high ozone levels in 2010, a study found. Ozone and other pollutants may also increase the risk of hospitalization and death for people infected with covid-19, .
Air pollution hits children, older adults, and people who work outside the hardest, and the impacts fall disproportionately on disadvantaged areas, whose residents often lack the resources to move to cleaner neighborhoods.
High levels of ozone also cause serious damage and death to vegetation.
Changing the Front Range’s ozone violator status from “serious” to “severe” could have some impact, some experts said. One result is that refineries would have to produce a special gasoline blend for cars in the nine counties of the Front Range that would be less volatile and contribute fewer precursors to the atmosphere. That could raise gas prices 5% to 10%.
“We’re going to go from some of the highest-emitting gasoline to the lowest-emitting gasoline” in the country, said Silverstein. “It won’t evaporate when it’s spilled on the ground and burns with fewer emissions. We’ll see ozone emissions benefits as soon as it’s at the station.” That may not be until next year or 2024.
Another consequence is that hundreds of companies that are not regulated under the current rules would come under the scrutiny of regulators and be forced to account for their emissions.
The Center for Biological Diversity and other environmental advocacy groups in an effort to force a “severe” ozone listing for the Front Range and other parts of the U.S. The lawsuit was filed before the EPA’s reclassification proposal.
Robert Ukeiley, an attorney for the Center for Biological Diversity, thinks the change in status will make a difference.
“When we get bumped up from ‘serious’ to ‘severe,’ it lowers the pollution threshold of what is considered a major source,” he said. “The state should have to issue major source permits, and that will start to reduce pollution.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/colorado-ozone-pollution-legislation-gaps-front-range/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1523121&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Flavor, however, is not the only thing the copper cup imparts. A study published in the January/February issue of the found that copper leaches into the drink made of ginger beer, lime juice, and vodka. In a little under half an hour, the copper levels rise higher than the safety standard set for drinking water.
A drink or two is not toxic, said one of the study’s authors, Carroll College associate chemistry professor . “Acute copper toxicity is very unlikely,” she said. “For that, you would need to drink 30 Moscow mules in a 24-hour period.”
After 27 minutes, the amount of copper leaching into the cup exceeds the 1.3 parts per million of copper that the Environmental Protection Agency sets as a safe level for drinking water.
The culprit? “Ginger beer seems to be the main driver in the leaching effect,” said , an author of the study and an associate professor of chemistry at Carroll, a Catholic university in Helena.
To avoid a coppery mule, Pharr recommends using a copper mug lined with stainless steel. Or make sure to down the mule in less than 27 minutes.
The idea of testing copper levels in the cocktail came to Pharr at a backyard gathering where Moscow mules were being served. “A friend said, ‘Don’t drink that — it leaches copper,’” she said. A discussion ensued. “I said, ‘I can figure out if that is true,’” she said. “It turns out that no one had ever quantified how much it was leaching.”
The researchers’ base in Montana is not just any serving drinks in a copper mug — the malleable metal plays a major role in the state’s history. The mining town of Butte — 70 miles south of Helena — was nicknamed because of the massive copper lode inside the hill upon which it was founded. The city was built with that wealth. Copper is still mined there, and some of it likely winds up in the copper mugs sold around the world for Moscow mules.
A bartender at Spud McGee’s cocktail lounge in Butte, not far from the city’s famed open pit mine, said she doesn’t serve that many Moscow mules. “We’re not really too worried about it honestly,” Amelia Hartwell said. “And we haven’t had any complaints about our Moscow mules.”
At , a Helena restaurant, owner Patrick Cassidy said Moscow mules are a popular cocktail and in December the restaurant sold an average of 17 a day. He said he’s thought about the possible effects from the copper. “But if someone comes in for drinks with dinner, they are only likely to have two or three,” he said. “But I have help who drink from copper cups all day, and I plan to caution them.”
What happens now that her study has been published, Pharr said, is up to health officials. “We’ve given them the tools to decide how to proceed,” she said.
Concerns have been expressed about the copper mugs before. In 2017, Iowa said the could not be used for Moscow mules because the FDA’s Food Code advised against food or drink with a pH of less than 6.0 — which are more acidic — from coming into contact with copper. The pH of a Moscow mule is 2.7
Ingesting copper is not entirely bad. It’s a matter of degree — copper is a necessary dietary ingredient. It’s found in shellfish, beans, nuts, and whole grains and sold in dietary supplements. It’s been shown to help prevent anemia and osteoporosis, among other ailments.
The research at Carroll was done with nine students over three semesters. Scientific protocols were carefully followed, Rowley said, and no one quaffed mules until the research was over. “We did drink Moscow mules at the end-of-the-semester party,” Rowley said.
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/news/dont-nurse-that-moscow-mule-it-could-be-a-health-hazard/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1444244&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Their victory in , later upheld by the state Supreme Court, resounded across the country, showing that young people have a stake in the issue of climate change, advocates say. Yet, state policies to address the causes of climate change in Montana — home to large coal, oil, and natural gas deposits — haven’t changed in the wake of the case.
On Sept. 17, some of those plaintiffs are scheduled to appear in federal court to request that U.S. District Judge Dana Christensen block a series of President Donald Trump’s executive orders on energy issues. They argue the orders violate their Fifth Amendment rights and will cause nearly 200,000 additional deaths over the next 25 years and lead to more heart, respiratory, and other health problems. They are joined by other plaintiffs ages 7 to 24 from California, Florida, Hawaii, and Oregon, and are backed by the climate-focused nonprofit Our Children’s Trust.
“Trump’s fossil fuel orders are a death sentence for my generation,” Eva Lighthiser, a 19-year-old resident of Livingston, Montana, wrote in the complaint filed on May 29. “I am not suing because I want to, I am suing because I have to. My health, my future and my right to speak the truth are all on the line.”
She added that a warming climate has led to an increase in summer wildfire smoke and contributed to the flooding of the Yellowstone River (a warmer atmosphere holds more precipitation). At the heart of the case, , is the claim that young people are being denied their Fifth Amendment rights under the U.S. Constitution — life, liberty, and the pursuit of happiness — because of the health effects of fossil fuel development and climate change. And they say the Montana Supreme Court’s decision in December to uphold their right to a clean and healthful environment buttresses their claim.

Montana Attorney General Austin Knudsen, a Republican, along with 18 other states and Guam, a U.S. territory, have sided with the Trump administration, filing a motion supporting the government’s request to dismiss the case. They argue the plaintiffs do not have standing to file the lawsuit, and that there is no constitutional right to a specific energy policy. “The state of Montana has an interest in this case because it will directly impact the business done in the energy sector within its borders,” Knudsen argued in his motion.
A hearing on the motion to dismiss, as well as the plaintiffs’ call for a stay of the executive orders, is scheduled for next week in federal court in Missoula.
Olivia Vesovich, 21, one of the plaintiffs, who is in her senior year at the University of Montana in Missoula, told ºÚÁϳԹÏÍø News she struggles with severe spring pollen allergies, which are exacerbated by climate warming and will likely worsen.
“My eyes were swollen shut every single day, every single night,” Vesovich said. “When I wake up in the morning, I couldn’t open my eyes for 10 minutes. It’s not fun at all, and it’s exacerbated by climate change and by the fossil fuel industry.”
She also has exercise-induced asthma as well as feelings of suffocation from the smoke-filled skies during wildfire season — of which are magnified by climate change. And Trump’s executive orders are already being implemented and causing harm, Vesovich said.
“We are making an argument that Olivia’s state constitutional right to a safe climate system should also be protected under the federal Fifth Amendment as part of her liberty right,” said Andrea Rodgers, a senior attorney for Our Children’s Trust.
Our Children’s Trust was also behind the climate change case Juliana v. the United States, filed in 2015 by 21 young plaintiffs who argued their rights had been violated. In 2024, the 9th U.S. Circuit Court of Appeals to dismiss the case, ruling that the courts were not the appropriate venue for climate policy.
They believe the victory in Held v. Montana gives American youth more standing this time. If they prevail, the result would be more far-reaching than the Montana case, creating a national precedent.

The plaintiffs are asking the court to declare Trump’s three related executive orders — “,” “,” and “” — unconstitutional and to block their implementation. They also claim that Trump has overstepped his authority by attempting to undo laws such as the Clean Air Act. A coalition of 14 states’ attorneys general has also filed a lawsuit against the order that declares an energy emergency.
Trump came into office in January sources and to back off efforts to usher in an era of renewable energy, which he claims are not viable. He has also rolling back environmental regulations. “We are driving a dagger into the heart of the climate change religion to drive down the cost of living for American families, unleash American energy, bring auto jobs back to the U.S., and more,” Environmental Protection Agency Administrator Lee Zeldin said in a March news release.
In July, the EPA proposed repealing its 2009 “” that concluded climate-warming gases “endanger both the public health and the public welfare of current and future generations.”
The finding established that greenhouse gases are a pollutant and create adverse effects, such as extreme weather and risks to human health and ecosystems. And it created a foundation to regulate automobiles and the energy sector to address climate change.
Zeldin said that eliminating the rule
Unleashing fossil fuels will come with costs, as well. The health effects of a warming world are thoroughly established , said Kristie Ebi, a University of Washington professor of global health and an expert in the health risks of climate variability. Mosquito-borne diseases such as dengue, chikungunya, and malaria are spreading, and flooding, droughts, and wildfire, exacerbated by climate change, pose threats. And research has shown an increase in deaths.
“There’s a long list of adverse health outcomes” from a warming world, she said. “The data are clear.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/courts/climate-activists-lawsuits-trump-energy-policies-fossil-fuels-violate-rights/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=2080061&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>At the top of the list of worries is a chemical called 6PPD, which is added to rubber tires to help them last longer. When tires wear on pavement, 6PPD is released. It reacts with ozone to become a different chemical, 6PPD-q, which can be extremely toxic — so much so that it has been linked to repeated fish kills in Washington state.
The trouble with tires doesn’t stop there. Tires are made primarily of natural rubber and synthetic rubber, but they contain hundreds of other ingredients, often including steel and heavy metals such as copper, lead, cadmium, and zinc.
As car tires wear, the rubber disappears in particles, both bits that can be seen with the naked eye and microparticles. Testing by a British company, Emissions Analytics, found that a car’s tires emit 1 trillion ultrafine particles per kilometer driven — from 5 to 9 pounds of rubber per internal combustion car per year.
And what’s in those particles is a mystery, because tire ingredients are proprietary.
“You’ve got a chemical cocktail in these tires that no one really understands and is kept highly confidential by the tire manufacturers,” said Nick Molden, CEO of Emissions Analytics. “We struggle to think of another consumer product that is so prevalent in the world and used by virtually everyone, where there is so little known of what is in them.”
Regulators have only begun to address the toxic tire problem, though there has been some action on 6PPD.
The chemical was identified by a team of researchers, led by scientists at Washington State University and the University of Washington, who were trying to determine why coho salmon returning to Seattle-area creeks to spawn were dying in large numbers.
Working for the Washington Stormwater Center, the scientists tested some 2,000 substances to determine which one was causing the die-offs, and in 2020 they announced they’d found the culprit: 6PPD.
The Yurok Tribe in Northern California, along with two other West Coast Native American tribes, have petitioned the Environmental Protection Agency to prohibit the chemical. The EPA said it is considering new rules governing the chemical. “We could not sit idle while 6PPD kills the fish that sustain us,” said Joseph L. James, chairman of the Yurok Tribe, in a statement. “This lethal toxin has no place in any salmon-bearing watershed.”
California has begun taking steps to regulate the chemical, last year classifying tires containing it as a “priority product,” which requires manufacturers to search for and test substitutes.
“6PPD plays a crucial role in the safety of tires on California’s roads and, currently, there are no widely available safer alternatives,” said Karl Palmer, a deputy director at the state’s Department of Toxic Substances Control. “For this reason, our framework is ideally suited for identifying alternatives to 6PPD that ensure the continued safety of tires on California’s roads while protecting California’s fish populations and the communities that rely on them.”
The U.S. Tire Manufacturers Association says it has mobilized a consortium of 16 tire manufacturers to carry out an analysis of alternatives. Anne Forristall Luke, USTMA president and CEO, said it “will yield the most effective and exhaustive review possible of whether a safer alternative to 6PPD in tires currently exists.”
Molden, however, said there is a catch. “If they don’t investigate, they aren’t allowed to sell in the state of California,” he said. “If they investigate and don’t find an alternative, they can go on selling. They don’t have to find a substitute. And today there is no alternative to 6PPD.”
California is also studying a request by the California Stormwater Quality Association to classify tires containing zinc, a heavy metal, as a priority product, requiring manufacturers to search for an alternative. Zinc is used in the vulcanization process to increase the strength of the rubber.
When it comes to tire particles, though, there hasn’t been any action, even as the problem worsens with the proliferation of electric cars. Because of their quicker acceleration and greater torque, electric vehicles wear out tires faster and emit an estimated 20% more tire particles than the average gas-powered car.
A in Southern California found tire and brake emissions in Anaheim accounted for 30% of PM2.5, a small-particulate air pollutant, while exhaust emissions accounted for 19%. Tests by Emissions Analytics have found that tires produce up to 2,000 times as much particle pollution by mass as tailpipes.
These particles end up in water and air and are often ingested. Ultrafine particles, even smaller than PM2.5, are also emitted by tires and can be inhaled and travel directly to the brain. suggests tire microparticles should be classified as a pollutant of “high concern.”
In a , researchers at Imperial College London said the particles could affect the heart, lungs, and reproductive organs and cause cancer.
People who live or work along roadways, often low-income, are exposed to more of the toxic substances.
Tires are also a major source of microplastics. of microplastics entering the ocean come from the synthetic rubber in tires, according to a report from the Pew Charitable Trusts and the British company Systemiq.
And there are still a great many unknowns in tire emissions, which can be especially complex to analyze because heat and pressure can transform tire ingredients into other compounds.
One outstanding research question is whether 6PPD-q affects people, and what health problems, if any, it could cause. A published in Environmental Science & Technology Letters found high levels of the chemical in urine samples from a region of South China, with levels highest in pregnant women.
The discovery of 6PPD-q, Molden said, has sparked fresh interest in the health and environmental impacts of tires, and he expects an abundance of new research in the coming years. “The jigsaw pieces are coming together,” he said. “But it’s a thousand-piece jigsaw, not a 200-piece jigsaw.”
This article was produced by ºÚÁϳԹÏÍø News, which publishes , an editorially independent service of the .Ìý
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/rural-health/tire-toxicity-salmon-die-offs-research-6ppd/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1843991&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>The BCG (Bacille Calmette-Guérin) vaccine, created in 1921, remains the sole TB vaccine. While it is 40% to 80% effective in young children, its efficacy is very low in adolescents and adults, leading to a worldwide push to create a more powerful vaccine.
One effort is underway at the University of Montana Center for Translational Medicine. The center specializes in improving and creating vaccines by adding what are called novel adjuvants. An adjuvant is a substance included in the vaccine, such as fat molecules or aluminum salts, that enhances the immune response, and novel adjuvants are those that have not yet been used in humans. Scientists are finding that adjuvants make for stronger, more precise, and more durable immunity than antigens, which create antibodies, would alone.
Eliciting specific responses from the immune system and deepening and broadening the response with adjuvants is known as precision vaccination. “It’s not one-size-fits-all,” said Ofer Levy, a professor of pediatrics at Harvard University and the head of the Precision Vaccines Program at Boston Children’s Hospital. “A vaccine might work differently in a newborn versus an older adult and a middle-aged person.”
The ultimate precision vaccine, said Levy, would be lifelong protection from a disease with one jab. “A single-shot protection against influenza or a single-shot protection against covid, that would be the holy grail,” Levy said.
Jay Evans, the director of the University of Montana center and the chief scientific and strategy officer and a co-founder of Inimmune, a privately held biotechnology company in Missoula, said his team has been working on a TB vaccine for 15 years. The private-public partnership is developing vaccines and trying to improve existing vaccines, and he said it’s still five years off before the TB vaccine might be distributed widely.
It has not gone unnoticed at the center that this state-of-the-art vaccine research and production is located in a state that passed one of the nation’s most extreme anti-vaccination laws during the pandemic in 2021. The law prohibits businesses and governments from discriminating against people who aren’t vaccinated against covid-19 or other diseases, effectively banning both public and private employers from requiring workers to get vaccinated against covid or any other disease. that the law cannot be enforced in health care settings, such as hospitals and doctors’ offices.
In mid-March, the Bill & Melinda Gates Medical Research Institute announced it had begun the third and final phase of clinical trials for the new vaccine in seven countries. The trials should take about five years to complete. Research and production are being done in several places, including at a manufacturing facility in Hamilton owned by GSK, a giant pharmaceutical company.
Known as the forgotten pandemic, TB kills up to 1.6 million people a year, mostly in impoverished areas in Asia and Africa, despite its being both preventable and treatable. The U.S. has seen an increase in tuberculosis over the past decade, especially with the influx of migrants, and the number of cases rose by 16% from 2022 to 2023. Tuberculosis is the leading cause of death among people living with HIV, whose risk of contracting a TB infection is 20 times as great as people without HIV.
“TB is a complex pathogen that has been with human beings for ages,” said Alemnew Dagnew, who heads the program for the new vaccine for the Gates Medical Research Institute. “Because it has been with human beings for many years, it has evolved and has a mechanism to escape the immune system. And the immunology of TB is not fully understood.”
The University of Montana Center for Translational Medicine and Inimmune together have 80 employees who specialize in researching a range of adjuvants to understand the specifics of immune responses to different substances. “You have to tailor it like tools in a toolbox towards the pathogen you are vaccinating against,” Evans said. “We have a whole library of adjuvant molecules and formulations.”
Vaccines are made more precise largely by using adjuvants. There are three basic types of natural adjuvants: aluminum salts; squalene, which is made from shark liver; and some kinds of saponins, which are fat molecules. It’s not fully understood how they stimulate the immune system. The center in Missoula has also created and patented a synthetic adjuvant, UM-1098, that drives a specific type of immune response and will be added to new vaccines.
One of the most promising molecules being used to juice up the immune system response to vaccines is a saponin molecule from the bark of the quillay tree, gathered in Chile from trees at least 10 years old. Such molecules were used by Novavax in its covid vaccine and by GSK in its widely used shingles vaccine, Shingrix. These molecules are also a key component in the new tuberculosis vaccine, known as the M72 vaccine.
But there is room for improvement.
“The vaccine shows 50% efficacy, which doesn’t sound like much, but basically there is no effective vaccine currently, so 50% is better than what’s out there,” Evans said. “We’re looking to take what we learned from that vaccine development with additional adjuvants to try and make it even better and move 50% to 80% or more.”
By contrast, measles vaccines are 95% effective.
According to Medscape, around 15 vaccine candidates are being developed to replace the BCG vaccine, and three of them are in phase 3 clinical trials.
One approach Evans’ center is researching to improve the new vaccine’s efficacy is taking a piece of the bacterium that causes TB, synthesizing it, and combining it with the adjuvant QS-21, made from the quillay tree. “It stimulates the immune system in a way that is specific to TB and it drives an immune response that is even closer to what we get from natural infections,” Evans said.
The University of Montana center is researching the treatment of several problems not commonly thought of as treatable with vaccines. They are entering the first phase of clinical trials for a vaccine for allergies, for instance, and first-phase trials for a cancer vaccine. And later this year, clinical trials will begin for vaccines to block the effects of opioids like heroin and fentanyl. The University of Montana received the largest grant in its history, $33 million, for anti-opioid vaccine research. It works by creating an antibody that binds with the drug in the bloodstream, which keeps it from entering the brain and creating the high.
For now, though, the eyes of health care experts around the world are on the trials for the new TB vaccines, which, if they are successful, could help save countless lives in the world’s poorest places.
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/new-better-tuberculosis-tb-vaccine-montana/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1840711&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>These hunters, however, are not just on the front lines of an American tradition. Infectious disease researchers say they are also on the front lines of what could be a serious threat to public health: chronic wasting disease.
The neurological disease, which is contagious, rapidly spreading, and always fatal, is caused by misfolded proteins called prions. It currently is known to infect only members of the cervid family — elk, deer, reindeer, caribou, and moose.
Animal disease scientists are alarmed about the rapid spread of CWD in deer. shows that the barrier to a spillover into humans is less formidable than previously believed and that the prions causing the disease may be evolving to become more able to infect humans.
A response to the threat is ramping up. In 2023, a coalition of researchers began “working on a major initiative, bringing together 68 different global experts on various aspects of CWD to really look at what are the challenges ahead should we see a spillover into humans and food production,” said , an expert in infectious disease at the University of Minnesota and a leading authority on CWD.
“The bottom-line message is we are quite unprepared,” Osterholm said. “If we saw a spillover right now, we would be in free fall. There are no contingency plans for what to do or how to follow up.”
The team of experts is planning for a potential outbreak, focusing on public health surveillance, lab capacity, prion disease diagnostics, surveillance of livestock and wildlife, risk communication, and education and outreach.
Despite the concern, tens of thousands of infected animals have been eaten by people in recent years, yet there have been no known human cases of the disease.
Many hunters have wrestled with how seriously to take the threat of CWD. “The predominant opinion I encounter is that no human being has gotten this disease,” said Steve Rinella, a writer and the founder of MeatEater, a media and lifestyle company focused on hunting and cooking wild game.
They think, “I am not going to worry about it because it hasn’t jumped the species barrier,” Rinella said. “That would change dramatically if a hunter got CWD.”
Other prion diseases, such as bovine spongiform encephalopathy, also known as mad cow disease, and Creutzfeldt-Jakob disease, have affected humans. Mad cow claimed the lives of , mostly in the United Kingdom and France. Some experts believe Parkinson’s and Alzheimer’s also may be caused by prions.
First discovered in Colorado in captive deer in 1967, CWD has since spread widely. It has been found in animals in at least 32 states, four Canadian provinces, and four other foreign countries. It was for the first time in Yellowstone National Park.
Prions behave very differently than viruses and bacteria and are virtually impossible to eradicate. Matthew Dunfee, director of the Chronic Wasting Disease Alliance, said experts call it a “disease from outer space.”
Symptoms are gruesome. The brain deteriorates to a spongy consistency. Sometimes nicknamed “zombie deer disease,” the condition makes infected animals stumble, drool, and stare blankly before they die. There is no treatment or vaccine. And it is extremely difficult to eradicate, whether with disinfectants or with high heat — it even survives autoclaving, or medical sterilization.
Cooking doesn’t kill prions, said Osterholm. Unfortunately, he said, “cooking concentrates the prions. It makes it even more likely” people will consume them, he said.
Though CWD is not known to have passed to humans or domestic animals, experts are very concerned about both possibilities, which Osterholm’s group just received more than $1.5 million in funding to study. CWD can infect more parts of an animal’s body than other prion diseases like mad cow, which could make it more likely to spread to people who eat venison — if it can jump to humans.
Researchers estimate that between 7,000 and 15,000 infected animals are unknowingly consumed by hunter families annually, a number that increases every year as the disease spreads across the continent. While testing of wild game for CWD is available, it’s cumbersome and the tests are not widely used in many places.
A major problem with determining whether CWD has affected humans is that it has a long latency. People who consume prions may not contract the resulting disease until many years later — so, if someone fell sick, there might not be an apparent connection to having eaten deer.
Prions are extremely persistent in the environment. They can remain in the ground for many years and even be taken up by plants.
Because the most likely route for spillover is through people who eat venison, quick testing of deer and other cervid carcasses is where prevention is focused. Right now, a hunter may drive a deer to a check station and have a lymph node sample sent to a lab. It can be a week or more before results come in, so most hunters skip it.
Montana, for example, is famous for its deer hunting. CWD was first detected in the wild there in 2017 and now has spread across much of the state. Despite warnings and free testing, Montana wildlife officials have not seen much concern among hunters. “We have not seen a decrease in deer hunting because of this,” said Brian Wakeling, game management bureau chief for the Montana Department of Fish, Wildlife & Parks. In 2022 Montana hunters killed nearly 88,000 deer. Just 5,941 samples were taken, and 253 of those tested positive.
Experts believe a rapid test would greatly increase the number of animals tested and help prevent spillover.
Because of the importance of deer to Indigenous people, several tribal nations in Minnesota are working with experts at the University of Minnesota to come up with ways to monitor and manage the disease. “The threat and potential for the spread of CWD on any of our three reservations has the ability to negatively impact Ojibwe culture and traditions of deer hunting providing venison for our membership,” said , a tribal biologist for the White Earth Nation, in a statement announcing the program. (The other groups referenced are the Leech Lake Band of Ojibwe and Red Lake Band of Chippewa.) “Tribes must be ready with a plan to manage and mitigate the effects of CWD … to ensure that the time-honored and culturally significant practice of harvesting deer is maintained for future generations.”
is an assistant professor in the College of Veterinary Medicine at the University of Minnesota and co-director of the . The center was formed to study numerous aspects of prions as part of the push to get ahead of possible spillover. “Our mission is to learn everything we can about not just CWD but other prionlike diseases, including Parkinson’s and Alzheimer’s disease,” he said. “We are studying the biology and ecology” of the misfolded protein, he said. “How do prions move within the environment? How can we help mitigate risk and improve animal health and welfare?”
Part of that mission is new technology to make testing faster and easier. Researchers have developed a way for hunters to do their own testing, though it can take weeks for results. There’s hope for, within the next two years, a test that will reduce the wait time to three to four hours.
“With all the doom and gloom around CWD, we have real solutions that can help us fight this disease in new ways,” said Larsen. “There’s some optimism.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/chronic-wasting-disease-deer-cervids-hunting-prions/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1803547&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Six-foot-tall corn plants tower over large green squash and black-and-yellow sunflowers. Around the perimeter, stalks of sweetgrass grow.
The seeds for some of these plants grew for millennia in Native Americans’ gardens along the upper Missouri River. It’s one of several Native American ancestral gardens growing in the Bozeman area, totaling about an acre. Though small, the garden is part of a larger, multifaceted effort around the country to promote “food sovereignty” for reservations and tribal members off reservation, and to reclaim aspects of Native American food and culture that flourished in North America for thousands of years before the arrival of European settlers. Restoring bison to reservations, developing community food gardens with ancestral seeds, understanding and collecting wild fruits and vegetables, and learning how to cook tasty meals with traditional ingredients are all part of the movement.
“We are learning to care for plant knowledge, growing Indigenous gardens, cultivating ancestral seeds — really old seeds from our relatives the Mandan, Hidatsa, and Arikara: corn, beans, squash, and sunflowers,” said Jill Falcon Ramaker, an assistant professor of community nutrition and sustainable food systems at Montana State. She is a member of the Turtle Mountain Band of Anishinaabe.
“A lot of what we are doing here at the university is cultural knowledge regeneration,” she said.
But it also has a very practical application: to provide healthier, cheaper, and more reliable food supplies for reservations, which are often a long way from supermarkets, and where processed foods have helped produce an epidemic of diabetes and heart disease.

Many reservations are food deserts where prices are high and processed food is often easier to come by than fresh food. , a 2020 paper funded by the U.S. Department of Agriculture, found that the median cost in the state of a collection of items typically purchased at a grocery store is 23% higher on a reservation than off.
“With food sovereignty we are looking at the ability to put that healthy food and ancestral foods which we used to survive for thousands of years, putting those foods back on the table,” Ramaker said. What that means exactly can vary by region, depending on the traditional food sources, from wild rice in the Midwest to salmon on the Pacific coast.
Central to the effort, especially in Montana, are bison, also referred to as buffalo. In 2014, 13 Native nations from eight reservations in the U.S. and Canada came together to sign the Buffalo Treaty, an agreement to return bison to 6.3 million acres that sought “to welcome BUFFALO to once again live among us as CREATOR intended by doing everything within our means so WE and BUFFALO will once again live together to nurture each other culturally and spiritually.”

Nearly a decade later, dozens of tribes have buffalo herds, including all seven reservations in Montana.
The buffalo-centered food system was a success for thousands of years, according to Ramaker, who directs both the regional program, known as the Buffalo Nations Food Systems Initiative — a collaboration with the Native American Studies Department and College of Education, Health and Human Development at Montana State — and the Montana-specific effort, known as the Montana Indigenous Food Sovereignty Initiative. It wasn’t a hand-to-mouth existence, she wrote in an article for Montana State, but a “knowledge of a vast landscape, including an intimate understanding of animals, plants, season, and climate, passed down for millennia and retained as a matter of life and death.”
With bison meat at the center of the efforts, the BNFSI is working to bring other foods from the northern Plains Native American diet in line with modern palates.
The BNFSI has received a $5 million grant from the U.S. Department of Agriculture to carry out that work, in partnership with Nueta Hidatsa Sahnish College in New Town, North Dakota.

Life on reservations is partly to blame for many Native people eating processed foods, Ramaker said. Food aid from the federal government, known as the Commodity Supplemental Food Program, has long been shipped to reservations in the form of boxes full of packaged foods. “We were forced onto the reservations, where there was replacement food sent by the government — white flour, white sugar, canned meat, salt, and baking powder,” she said.
processed foods contribute to chronic inflammation, which in turn leads to heart disease, cancer, and diabetes, which occurs at in Native Americans as it does in white people.
Studies show that people’s mental and physical health declines when they consume a processed food diet. “In the last decade there’s a growing amount of research on the impact of good nutrition on suicide ideation, attempts, and completion,” said KayAnn Miller, co-executive director of the Montana Partnership to End Childhood Hunger in Bozeman, who is also involved with the BNFSI.

All Native American reservations in Montana now have community gardens, and there are at least eight gardens on the Flathead Reservation north of Missoula, home to the Confederated Salish and Kootenai Tribes. The tribe is teaching members to raise vegetables, some of them made into soup that is delivered to tribal elders. This year members grew 5 tons of produce to be given away.
Ancestral seeds are part of the effort. Each year the BNFSI sends out 200 packets of seeds for ancestral crops to Indigenous people in Montana.
Creating foods that appeal to contemporary tastes is critical to the project. The BNFSI is working with Sean Sherman, the “Sioux Chef,” to turn corn, meat, and other Native foods into appealing dishes.
Sherman founded the award-winning Owamni restaurant in Minneapolis and in 2020 opened the Indigenous Food Lab, through his nonprofit, North American Traditional Indigenous Food Systems. The lab, in downtown Minneapolis, is also a restaurant and an education and training center that creates dishes using only Indigenous foods from across the country — no dairy, cane sugar, wheat flour, beef, chicken, or other ingredients from what he calls the colonizers.
“We’re not cooking like it’s 1491,” Sherman said last year on the NPR program “Fresh Air,” referring to the period before European colonization. “We’re not a museum piece or something like that. We’re trying to evolve the food into the future, using as much of the knowledge from our ancestors that we can understand and just applying it to the modern world.” Among his signature dishes are bison pot roast with hominy and roast turkey with a berry-mint sauce and black walnuts.
The Bozeman-based nonprofit HRDC built a $29 million building with a state-of-the-art kitchen that will house the country’s second Indigenous food lab, Ramaker said. It will open next year and expand the ongoing work creating recipes, holding cooking workshops, and preparing cooking videos.

Angelina Toineeta, who is Crow, is studying the BNFSI at Montana State as part of her major in agriculture. “Growing these gardens really stuck out to me,” she said. “Native American agriculture is something we’ve lost over the years, and I want to help bring that back.”
This <a target="_blank" href="/rural-health/native-indigenous-food-sovereignty-movement-bison-sioux-chef/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1763569&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>During her time in the Florida Legislature, Cruz had supported a new law allowing the use of treated wastewater in local water systems. But many Tampa residents were staunchly opposed to a plan by their water utility to do just that, and Cruz was forced to backtrack, with her spokesperson asserting she had never favored the type of complete water reuse known as “toilet to tap.” She lost anyway, and the water plan has been canceled.
Tampa’s showdown may be a harbinger of things to come as climate change and drought cause water shortages in many parts of the country. With few alternatives for expanding supply, cities and states are rapidly adding recycled water to their portfolios and expanding the ways in which it can be used. Researchers say it’s safe — and that it’s essential to move past the 20th century notion that wastewater must stay flushed.
“There is no reason to only use water once,” said Peter Fiske, director of the National Alliance for Water Innovation at the Lawrence Berkeley National Laboratory. “We’ve got to be more clever with the water we’ve got.”
But proponents are still fighting an uphill battle to overcome the “yuck” factor. A found that reused water is not only safe but that it’s actually cleaner than conventionally sourced water — yet acceptance is “hindered by perceptions of poor water quality and potential health threats.”
Several projects were canceled in California in the 1990s because of such worries. In San Gabriel, Miller Brewing Company opposed a water reclamation project when people started joking about “beer aged in porcelain.”
“You have to have a lot of education in a community to say why [recycled water] is needed” and what experts are doing to ensure the safety of the water, said Noelle George, the Texas managing director for the trade association WateReuse.
Many forms of water reuse have long been routine. Water from yard sprinklers, for example, soaks into the groundwater. Or, if it is processed in a treatment plant, it goes into a river or lake, where it’s used again. Municipalities and others often treat a form of wastewater known as gray water to use for irrigation.
But in the world of water reuse, the gold standard is known as direct potable reuse — cleaning wastewater, including sewage, to drinking water standards.
With DPR systems, the water from showers, sinks, and toilets first goes to a conventional treatment plant, where it is disinfected with chemicals and aeration. Then it gets a second scrubbing in a multistage process that first uses a bioreactor to break down nitrogen compounds, then employs microfiltration to clean out particles and reverse osmosis to remove viruses, bacteria, and salts. Finally, hydrogen peroxide is added and the water goes through an ultraviolet light processing, which is supposed to kill any contaminants that are left.
Experts say the water that emerges at the end of this process is so clean it has no taste, and that minerals must be added to give the water flavor. It’s also free of a little-known health hazard; chlorine, often used to disinfect conventional water, can react with organic material in the water to create chloroform, exposure to which can cause negative health effects.
Big Spring, Texas, is the only place in the country with a DPR municipal water system, in which all wastewater is treated and sent back to the tap. Another notable DPR system is the Changi Water Reclamation Plant in Singapore, which cleans 237 million gallons each day.
In Tampa, intense opposition focused on the high cost of the water treatment and the possible presence of pharmaceuticals, hormones, and so-called forever chemicals, .
“We have never thought that it was necessary to drink wastewater,” said Gary Gibbons, the vice chair of the Tampa Bay Sierra Club, in September 2022. He said the project, which the city referred to by the acronym PURE, would result in contaminants in the drinking water and the groundwater aquifer.
Experts reject these concerns as uninformed and say properly treated wastewater is safer than a lot of conventional drinking water sources.
“I would almost rather have an advanced treatment plant of the type used for potable water recycling than water that comes from a river that has several cities and farms and industries upstream that are discharging into it,” said David L. Sedlak, an expert on potable reuse at the University of California-Berkeley.
With higher temperatures and long-term pressure on water sources including aquifers and mountain snowpacks, a lot more water reuse is coming.
In Texas, the state permits DPR plants on a case-by-case basis, and the city of El Paso is building one that’s slated to be online by 2026. Colorado last year DPR. In California, regulations spelling out the approach to DPR by the end of this year, with some cities setting goals of recycling all water by 2035. Florida and Arizona are also moving to expand direct potable reuse.
There’s also a lot of activity around what’s known as indirect potable reuse. Orange County, California, has the world’s largest IPR facility, which cleans 130 million gallons of water a day to irrigation standards, passes it through advanced purification, and finally injects it into groundwater, which serves as an environmental buffer. The water is then piped to all municipal users.
San Francisco is pioneering another approach. Since 2015, the San Francisco Public Utilities Commission, which operates the dams, reservoirs, and aqueducts that deliver water from the Sierra Nevada to the city, has required all buildings over 100,000 square feet be equipped for recycling gray water. The downtown Salesforce Tower has its own recycling plant: Sinks, laundry machines, and showers drain into the basement recycling system, and the water is then reused for flushing toilets and irrigation, saving about 30,000 gallons a day.
“We don’t need to flush toilets with drinking water,” said Fiske, noting that toilets make up about 30% of all water use.
San Francisco water officials are studying the feasibility and safety of cleaning all wastewater to potable standards at the building level. The headquarters of the water utility has a blackwater system called the Living Machine that uses engineered wetlands in the sidewalks around the building to treat wastewater, cutting water use by two-thirds. (Blackwater systems recycle water from toilets; gray water systems reuse water from all other drains.)
Some experts see a day when buildings will not have to be hooked up to external sewer and water systems at all, with advanced recycling systems augmented by rainwater. For the moment, though, educational campaigns are still needed to bring recycled water into the mainstream.
Epic Cleantec, which created a recycling system for a new San Francisco apartment tower, thought beer might help. The company last year teamed up with a local brewery to produce beer from recycled water. The Epic OneWater Brew by Devil’s Canyon Brewing isn’t sold; rather, it’s a demonstration product, given away and served at events.
While people might not want to drink recycled water, they will usually try the beer.
“We made beer out of recycled water, because we’re trying to change the conversation,” said Aaron Tartakovsky, CEO of Epic Cleantec. “We’re fundamentally trying to help people rethink how our communities handle water.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/health-industry/water-direct-potable-reuse-expands-yuk-factor/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
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In the 1990s, residents of Mexico City noticed their dogs acting strangely — some didn’t recognize their owners, and the animals’ sleep patterns had changed.
At the time, the sprawling, mountain-ringed city of more than 15 million people was known as the most polluted in the world, with a thick, constant haze of fossil fuel pollution trapped by thermal inversions.
In 2002, toxicologist and neuropathologist Lilian Calderón-Garcidueñas, who is affiliated with both Universidad del Valle de México in Mexico City and the University of Montana, examined brain tissue from 40 dogs that had lived in the city and 40 others from a nearby rural area with cleaner air. She discovered the brains of the city dogs showed signs of neurodegeneration while the rural dogs had far healthier brains.
Calderón-Garcidueñas went on to of 203 human residents of Mexico City, only one of which did not show signs of neurodegeneration. That led to the conclusion that chronic exposure to air pollution can negatively affect people’s olfactory systems at a young age and may make them more susceptible to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
The pollutant that plays the “big role” is particulate matter, said Calderón-Garcidueñas. “Not the big ones, but the tiny ones that can cross barriers. We can detect nanoparticles inside neurons, inside glial cells, inside epithelial cells. We also see things that shouldn’t be there at all — titanium, iron, and copper.”
The work the Mexican scientist is doing is feeding a burgeoning body of evidence that shows breathing polluted air not only causes heart and lung damage but also neurodegeneration and mental health problems.
It’s that air pollution takes a serious toll on the human body, affecting almost every organ. Asthma, cardiovascular disease, cancer, premature death, and stroke are among a long list of problems that can be caused by exposure to air pollution, which, according to the World Health Organization, sits atop the list of health threats globally, causing 7 million deaths a year. Children and infants are especially susceptible.
Sussing out the impact of air pollution on the brain has been more difficult than for other organs because of its inaccessibility, so it has not been researched as thoroughly, according to researchers. Whether air pollution may cause or contribute to Alzheimer’s or Parkinson’s is not settled science. But Calderón-Garcidueñas’ work is at the leading edge of showing that air pollution goes directly into the brain through the air we breathe, and has serious impacts.
Some psychotherapists report seeing patients with symptoms stemming from air pollution. Not only does the pollution appear to cause symptoms or make them worse; it also takes away forms of relief.
“If we exercise and spend time in nature we become extra resilient,” said Kristen Greenwald, an environmental social worker and adjunct professor at the University of Denver. “A lot of folks do that outside. That’s their coping mechanism; it’s soothing to the nervous system.”
On polluted days a lot of her clients “can’t go outside without feeling they are making themselves more sick or distressed.”
Megan Herting, who researches air pollution’s impact on the brain at the University of Southern California, said environmental factors should be incorporated in doctors’ assessments these days, especially in places like Southern California and Colorado’s Front Range, where high levels of air pollution are a chronic problem.
“When I go into a medical clinic, they rarely ask me where I live and what is my home environment like,” she said. “Where are we living, what we are exposed to, is important in thinking about prevention and treatment.”
In the last two decades, with new technologies, research on air pollution and its impact on the human nervous system has grown by leaps and bounds.
Research shows tiny particles as they are breathed in through the nose and mouth and travel directly into the brain. Fine and ultrafine particles, which come from diesel exhaust, soot, dust, and wildfire smoke, among other sources, often contain metals that hitchhike a ride, worsening their impact.
A changing climate is likely to exacerbate the effects of air pollution on the brain and mental health. Warmer temperatures react with tailpipe emissions from cars to create more ozone than is generated when it’s cooler. And more and larger forest fires are expected to mean more days of smoky skies.
Ozone has been , decline in cerebral plasticity, the death of neurons, and learning and memory impairment. Ozone levels are extremely high in Los Angeles and the mountain valleys of the West, including the Front Range of Colorado, Phoenix, and Salt Lake City.
Air pollution also causes damage from chronic inflammation. As air pollution particles enter the brain, they are mistaken for germs and attacked by microglia, a component of the brain’s immune system, and they stay activated.
“Your body doesn’t like to be exposed to air pollution and it produces an inflammatory response,” said Patrick Ryan, a researcher at Cincinnati Children’s Hospital, in an email. “Your brain doesn’t like it either. There’s more than 10 years of toxicological science and epidemiologic studies that show air pollution causes neuro-inflammation.”
Much of the current research focuses on how pollution causes mental health problems.
Damage to the brain is especially pernicious because it is the master control panel for the body, and pollution damage can cause a range of neuropsychiatric disorders. A primary focus of research these days is how pollution-caused damage affects areas of the brain that regulate emotions — such as the amygdala, prefrontal cortex, and hippocampus. The amygdala, for example, governs the processing of fearful experiences, and its impairment can cause anxiety and depression. In one recent review, looking at both physical and functional changes to areas of the brain that regulate emotion showed an impact from air pollution.
published in February in JAMA Psychiatry, by researchers from the universities of Oxford and Peking and Imperial College London, tracked the incidence of anxiety and depression in nearly 400,000 adults in the United Kingdom over a median length of 11 years and found that long-term exposure even to low levels of a combination of air pollutants — particulate matter, nitrogen dioxide, and nitric oxide — increased the occurrence of depression and anxiety.
Another recent study, by Erika Manczak at the University of Denver, found adolescents exposed to ozone predicted “for steeper increases in depressive symptoms across adolescent development.”
But the epidemiological research has shortcomings because of confounding factors that are difficult to account for. Some people may be genetically predisposed to susceptibility and others not. Some may experience chronic stress or be very young or very old, which can increase their susceptibility. People who reside near a lot of green space, which reduces anxiety, may be less susceptible.
“Folks living in areas where there is greater exposure to pollutants tend to be areas under-resourced in many ways and grappling with a lot of systemic problems. There are bigger reports of stress and depression and anxiety,” said Manczak. “Given that those areas have been marginalized for a lot of reasons, it’s a little hard to say this is due to air pollution exposure.”
The best way to tell for sure would be to conduct clinical trials, but that comes with ethical problems. “We can’t randomly expose kids to air pollution,” Ryan said.
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/mental-health/air-pollution-mental-health-impact-research-depression-anxiety/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1674935&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Bats worldwide are primary vectors for virus transmission from animals to humans. Those viruses often are harmless to bats but can be deadly to humans. Horseshoe bats in China, for example, are cited as a likely cause of the covid-19 outbreak. And researchers believe pressure put on bats by climate change and encroachment from human development have increased the frequency of viruses jumping from bats to people, causing what are known as zoonotic diseases.
“Spillover events are the result of a cascade of stressors — bat habitat is cleared, climate becomes more extreme, bats move into human areas to find food,” said Raina Plowright, a disease ecologist and co-author of a recent paper in the and another in on the role of ecological changes in disease.
That’s why Montana State University immunologist Agnieszka Rynda-Apple plans to bring the Jamaican fruit bats to Bozeman this winter to start a breeding colony and accelerate her lab’s work as part of a team of 70 researchers in seven countries. The group, called BatOneHealth — founded by Plowright — hopes to find ways to predict where the next deadly virus might make the leap from bats to people.
“We’re collaborating on the question of why bats are such a fantastic vector,” said Rynda-Apple. “We’re trying to understand what is it about their immune systems that makes them retain the virus, and what is the situation in which they shed the virus.”
To study the role of nutritional stress, researchers create different diets for them, she said, “and infect them with the influenza virus and then study how much virus they are shedding, the length of the viral shedding, and their antiviral response.”
While she and her colleagues have already been doing these kinds of experiments, breeding bats will allow them to expand the research.
It’s a painstaking effort to thoroughly understand how environmental change contributes to nutritional stress and to better predict spillover. “If we can really understand all the pieces of the puzzle, that gives us tools to go back in and think about eco-counter measures that we can put in place that will break the cycle of spillovers,” said Andrew Hoegh, an assistant professor of statistics at MSU who is creating models for possible spillover scenarios.
The small team of researchers at MSU works with a researcher at the National Institutes of Health’s Rocky Mountain Laboratories in Hamilton, Montana.
The recent papers published in Nature and Ecology Letters focus on the Hendra virus in Australia, which is where Plowright was born. Hendra is a respiratory virus that causes flu-like symptoms and spreads from bats to horses, and then can be passed on to people who treat the horses. It is deadly, with a mortality rate of . Of the seven people known to have been infected, four died.
The question that propelled Plowright’s work is why Hendra began to show up in horses and people in the 1990s, even though bats have likely hosted the virus for eons. The research demonstrates that the reason is environmental change.
Plowright began her bat research in 2006. In samples taken from Australian bats called flying foxes, she and her colleagues rarely detected the virus. After Tropical Cyclone Larry off the coast of the Northern Territory wiped out the bats’ food source in 2005-06, hundreds of thousands of the animals simply disappeared. However, they found one small population of weak and starving bats loaded with the Hendra virus. That led Plowright to focus on nutritional stress as a key player in spillover.
She and her collaborators scoured 25 years of data on habitat loss, spillover, and climate and discovered a link between the loss of food sources caused by environmental change and high viral loads in food-stressed bats.
In the year after an climate pattern, with its high temperatures — occurring every few years — many eucalyptus trees don’t produce the flowers with nectar the bats need. And human encroachment on other habitats, from farms to urban development, has eliminated alternative food sources. And so the bats tend to move into urban areas with substandard fig, mango, and other trees, and, stressed, shed virus. When the bats excrete urine and feces, horses inhale it while sniffing the ground.
The researchers hope their work with Hendra-infected bats will illustrate a universal principle: how the destruction and alteration of nature can increase the likelihood that deadly pathogens will spill over from wild animals to humans.
The three most likely sources of spillover are bats, mammals, and arthropods, especially ticks. Some that infect humans come from animals, and about two-thirds of those come from wild animals.
The idea that deforestation and human encroachment into wild land fuels pandemics is not new. For example, experts believe that HIV, which causes AIDS, first infected humans when people ate chimpanzees in central Africa. A Malaysian outbreak in late 1998 and early 1999 of the bat-borne Nipah virus spread from bats to pigs. The pigs amplified it, and it spread to humans, infecting 276 people and killing 106 in that outbreak. Now emerging is the connection to stress brought on by environmental changes.
One critical piece of this complex puzzle is bat immune systems. The Jamaican fruit bats kept at MSU will help researchers learn more about the effects of nutritional stress on their viral load.
Vincent Munster, chief of the virus ecology unit of Rocky Mountain Laboratories and a member of BatOneHealth, is also looking at different species of bats to better understand the ecology of spillover. “There are 1,400 different bat species and there are very significant differences between bats who harbor coronaviruses and bats who harbor Ebola virus,” said Munster. “And bats who live with hundreds of thousands together versus bats who are relatively solitary.”
Meanwhile, Plowright’s husband, Gary Tabor, is president of the Center for Large Landscape Conservation, a nonprofit that applies ecology of disease research to protect wildlife habitat — in part, to assure that wildlife is adequately nourished and to guard against virus spillover.
“Habitat fragmentation is a planetary health issue that is not being sufficiently addressed, given the world continues to experience unprecedented levels of land clearing,” said Tabor.
As the ability to predict outbreaks improves, other strategies become possible. Models that can predict where the Hendra virus could spill over could lead to vaccination for horses in those areas.
Another possible solution is the set of “eco-counter measures” Hoegh referred to — such as large-scale planting of flowering eucalyptus trees so flying foxes won’t be forced to seek nectar in developed areas.
“Right now, the world is focused on how we can stop the next pandemic,” said Plowright. “Unfortunately, preserving or restoring nature is rarely part of the discussion.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/a-secret-weapon-in-preventing-the-next-pandemic-fruit-bats/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1614995&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>But new Colorado laws aimed at improving air quality along that urban corridor east of the Rocky Mountains aren’t expected to do much to directly reduce ozone, according to experts charged with bringing down the levels. “These are not the magic bullets that will bring us into compliance, but they will be helpful in reducing emissions,” said Michael Silverstein, executive director of the Regional Air Quality Council, the lead air-quality planning organization for nine counties of the Front Range.
In the most recent legislative session, Colorado lawmakers passed three bills aimed at improving air quality: One replaces highly polluting diesel buses with electric buses, another provides funding so residents can access public transportation free of charge for a month during the high-ozone season, and the third creates a system to alert the public to toxic emissions released from industrial sources.
to reclassify nine counties of the Front Range, including Denver, from “serious” violators of federal ozone standards to “severe” violators would bring more significant change, Silverstein said. (The EPA’s begin with “serious” and then move to “severe” and “extreme.”)
But other health experts say neither the federal nor the state actions will be enough to truly safeguard public health.
“At some point, you are just putting band-aids on, and this feels like that,” said James Crooks, an air pollution researcher at National Jewish Health, a Denver hospital that specializes in respiratory disorders. “Better to have the band-aids than not, but it’s not going to solve the problem.”
Ozone is created when chemicals emitted into the atmosphere via vehicle exhaust, oil and gas development, and wildfires are baked by the sun. Ozone pollution that exceeds federal limits is a stubborn problem in Mountain West valleys, especially in Phoenix; Albuquerque, New Mexico; Salt Lake City; and Denver.
The Front Range has one of the worst ozone problems in the country. Last year, health officials in the counties east of the Rocky Mountains issued “ozone action day alerts” on 65 days from May 31 to Aug. 31, peak season for ozone. That’s the highest number since record-keeping began in 2011.
The EPA determined that over the three-year period from 2018 to 2020, average ozone levels over eight hours on the Front Range were 81 parts per billion. The federal limit set in 2008 was 75 ppb, but the current one, set in 2015, is 70 ppb. Under the proposal to change a nine-county area of the Front Range from a “serious” to a “severe” violator, the region would have to meet that standard by 2026.
A final decision on the proposal is expected from the EPA this fall.
“Ground-level ozone remains one of the most challenging public health concerns we face, affecting large numbers of Coloradans and their families,” EPA Regional Administrator KC Becker said in an April news release announcing the proposed change.
Crooks said that 70 ppb is a difficult goal to achieve and that it isn’t low enough to protect public health. Indeed, no level of ozone is safe, he said. “We might be able to muddle through and get to 75,” said Crooks. “But 70 is going to be really hard to do without decarbonization,” which means replacing gas and diesel vehicles with electric vehicles.
One challenge in reducing ozone is trying to control the emission of ozone precursors from myriad sources. Thousands of oil and gas wells are along the Front Range, some in suburban neighborhoods, and their emissions, along with vehicle emissions, are the primary sources of ozone.
Complicating the matter is that one-half to two-thirds of the ozone that plagues the Front Range comes from outside the state, some from as far away as Asia. The background levels of ozone — naturally or human-created ozone that originates from outside the region — can be as high as 60 ppb.
Another problem is the wildfire smoke that blankets the state each summer. And rising temperatures, a result of climate change, are causing more ozone to be produced.
Ground-level ozone is the same chemical as the ozone that is high in the atmosphere, but up there, it provides a crucial shield that protects the Earth from harmful ultraviolet rays.
On the ground, the odorless gas can cause shortness of breath and stinging in the eyes and can trigger asthma attacks. It predisposes people to pulmonary inflammation and coronary damage. Globally, were caused by high ozone levels in 2010, a study found. Ozone and other pollutants may also increase the risk of hospitalization and death for people infected with covid-19, .
Air pollution hits children, older adults, and people who work outside the hardest, and the impacts fall disproportionately on disadvantaged areas, whose residents often lack the resources to move to cleaner neighborhoods.
High levels of ozone also cause serious damage and death to vegetation.
Changing the Front Range’s ozone violator status from “serious” to “severe” could have some impact, some experts said. One result is that refineries would have to produce a special gasoline blend for cars in the nine counties of the Front Range that would be less volatile and contribute fewer precursors to the atmosphere. That could raise gas prices 5% to 10%.
“We’re going to go from some of the highest-emitting gasoline to the lowest-emitting gasoline” in the country, said Silverstein. “It won’t evaporate when it’s spilled on the ground and burns with fewer emissions. We’ll see ozone emissions benefits as soon as it’s at the station.” That may not be until next year or 2024.
Another consequence is that hundreds of companies that are not regulated under the current rules would come under the scrutiny of regulators and be forced to account for their emissions.
The Center for Biological Diversity and other environmental advocacy groups in an effort to force a “severe” ozone listing for the Front Range and other parts of the U.S. The lawsuit was filed before the EPA’s reclassification proposal.
Robert Ukeiley, an attorney for the Center for Biological Diversity, thinks the change in status will make a difference.
“When we get bumped up from ‘serious’ to ‘severe,’ it lowers the pollution threshold of what is considered a major source,” he said. “The state should have to issue major source permits, and that will start to reduce pollution.”
ºÚÁϳԹÏÍø News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about .This <a target="_blank" href="/public-health/colorado-ozone-pollution-legislation-gaps-front-range/">article</a> first appeared on <a target="_blank" href="">KFF Health News</a> and is republished here under a <a target="_blank" href=" Commons Attribution-NonCommercial-NoDerivatives 4.0 International License</a>.<img src="/wp-content/uploads/sites/8/2023/04/kffhealthnews-icon.png?w=150" style="width:1em;height:1em;margin-left:10px;">
<img id="republication-tracker-tool-source" src="/?republication-pixel=true&post=1523121&ga4=G-J74WWTKFM0" style="width:1px;height:1px;">]]>Flavor, however, is not the only thing the copper cup imparts. A study published in the January/February issue of the found that copper leaches into the drink made of ginger beer, lime juice, and vodka. In a little under half an hour, the copper levels rise higher than the safety standard set for drinking water.
A drink or two is not toxic, said one of the study’s authors, Carroll College associate chemistry professor . “Acute copper toxicity is very unlikely,” she said. “For that, you would need to drink 30 Moscow mules in a 24-hour period.”
After 27 minutes, the amount of copper leaching into the cup exceeds the 1.3 parts per million of copper that the Environmental Protection Agency sets as a safe level for drinking water.
The culprit? “Ginger beer seems to be the main driver in the leaching effect,” said , an author of the study and an associate professor of chemistry at Carroll, a Catholic university in Helena.
To avoid a coppery mule, Pharr recommends using a copper mug lined with stainless steel. Or make sure to down the mule in less than 27 minutes.
The idea of testing copper levels in the cocktail came to Pharr at a backyard gathering where Moscow mules were being served. “A friend said, ‘Don’t drink that — it leaches copper,’” she said. A discussion ensued. “I said, ‘I can figure out if that is true,’” she said. “It turns out that no one had ever quantified how much it was leaching.”
The researchers’ base in Montana is not just any serving drinks in a copper mug — the malleable metal plays a major role in the state’s history. The mining town of Butte — 70 miles south of Helena — was nicknamed because of the massive copper lode inside the hill upon which it was founded. The city was built with that wealth. Copper is still mined there, and some of it likely winds up in the copper mugs sold around the world for Moscow mules.
A bartender at Spud McGee’s cocktail lounge in Butte, not far from the city’s famed open pit mine, said she doesn’t serve that many Moscow mules. “We’re not really too worried about it honestly,” Amelia Hartwell said. “And we haven’t had any complaints about our Moscow mules.”
At , a Helena restaurant, owner Patrick Cassidy said Moscow mules are a popular cocktail and in December the restaurant sold an average of 17 a day. He said he’s thought about the possible effects from the copper. “But if someone comes in for drinks with dinner, they are only likely to have two or three,” he said. “But I have help who drink from copper cups all day, and I plan to caution them.”
What happens now that her study has been published, Pharr said, is up to health officials. “We’ve given them the tools to decide how to proceed,” she said.
Concerns have been expressed about the copper mugs before. In 2017, Iowa said the could not be used for Moscow mules because the FDA’s Food Code advised against food or drink with a pH of less than 6.0 — which are more acidic — from coming into contact with copper. The pH of a Moscow mule is 2.7
Ingesting copper is not entirely bad. It’s a matter of degree — copper is a necessary dietary ingredient. It’s found in shellfish, beans, nuts, and whole grains and sold in dietary supplements. It’s been shown to help prevent anemia and osteoporosis, among other ailments.
The research at Carroll was done with nine students over three semesters. Scientific protocols were carefully followed, Rowley said, and no one quaffed mules until the research was over. “We did drink Moscow mules at the end-of-the-semester party,” Rowley said.
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