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Why Brittle Bones Aren鈥檛 Just a Woman鈥檚 Problem

Ronald Klein was biking around his neighborhood in North Wales, Pennsylvania, in 2006 and tried to jump a curb. 鈥淏ut I was going too slow 鈥 I didn鈥檛 have enough momentum,鈥 he recalled.

As the bike toppled, he thrust out his left arm to break the fall. It didn鈥檛 seem like a serious accident, yet 鈥淚 couldn鈥檛 get up,鈥 he said.

At the emergency room, X-rays showed that he had fractured both his hip, which required surgical repair, and his shoulder. Klein, a dentist, went back to work in three weeks, using a cane. After about six months and plenty of physical therapy, he felt fine.

But he wondered about the damage the fall had caused. 鈥淎 52-year-old is not supposed to break a hip and a shoulder,鈥 he said. At a follow-up visit with his orthopedist, 鈥淚 said, 鈥楳aybe I should have a bone density scan.鈥欌

As Klein suspected, the test showed he had developed osteoporosis, a progressive condition, increasing sharply with age, that thins and weakens bones and can lead to serious fractures. Klein immediately began a drug regimen and, now 70, remains on one.

Osteoporosis occurs so much more commonly in women, for whom medical guidelines recommend , that a man who was not a health care professional might not have thought about getting a scan. The orthopedist didn鈥檛 raise the prospect.

But about will suffer an osteoporotic fracture in their remaining years, and among older adults, about .

When they do, 鈥渕en have worse outcomes,鈥 said Cathleen Col贸n-Emeric, a geriatrician at the Durham VA Health Care System and Duke University and the lead author of a recent study of osteoporosis treatment in male veterans.

鈥淢en don鈥檛 do as well in recovery as women,鈥 she said, with (25% to 30% within a year), disability and institutionalization. 鈥淎 50-year-old man is more likely to die from the complications of a major osteoporotic fracture than from prostate cancer,鈥 she said.

(What鈥檚 鈥渕ajor鈥? Fractures of the wrist, hip, femur, humerus, pelvis or vertebra.)

In her ages 65 to 85, conducted at Veterans Affairs health centers in North Carolina and Virginia, only 2% of those assigned to the control group had undergone bone-density screening.

鈥淪hockingly low,鈥 said Douglas Bauer, a clinical epidemiologist and osteoporosis researcher at the University of California-San Francisco, who published in JAMA Internal Medicine. 鈥淎bysmal. And that鈥檚 at the VA, where it鈥檚 paid for by the government.鈥

But establishing a bone health service 鈥 overseen by a nurse who entered orders, sent frequent appointment reminders and explained results 鈥 led to dramatic changes in the intervention group, who had at least one risk factor for the condition.

Forty-nine percent of them said yes to a scan. Half of those tested had osteoporosis or a forerunner condition, osteopenia. Where appropriate, most of them began medications to preserve or rebuild their bones.

鈥淲e were pleasantly surprised that so many agreed to be screened and were willing to initiate treatment,鈥 Col贸n-Emeric said.

After 18 months, bone density had increased modestly for those in the intervention group, who were more likely to stick to their drug regimens than osteoporosis patients of either sex in real-world conditions.

The study didn鈥檛 continue long enough to determine whether bone density increased further or fractures declined, but the researchers plan a secondary analysis to track that.

The results revive a longtime question: Given how life-altering, even deadly, such fractures can be, and the availability of effective drugs to slow or reverse bone loss, should older men be screened for osteoporosis, as women are? If so, which men and when?

Such issues mattered less when life spans were shorter, Bauer explained. Men have bigger and thicker bones and tend to develop osteoporosis five to 10 years later than women do. 鈥淯ntil recently, those men died of heart disease and smoking鈥 before osteoporosis could harm them, he said.

鈥淣ow, men routinely live into their 70s and 80s, so they have fractures,鈥 he added. By then, they have also accumulated other chronic conditions that impair their ability to recover.

With osteoporosis testing and treatment, 鈥渁 man could see a clear-cut improvement in mortality and, more importantly, his quality of life,鈥 Bauer said.

Both patients and many doctors still tend to regard osteoporosis as a women鈥檚 disease, however. 鈥淭here鈥檚 a bit of a Superman idea,鈥 said Eric Orwoll, an endocrinologist and osteoporosis researcher at Oregon Health & Science University.

鈥淢en would like to believe they鈥檙e indestructible, so a fracture doesn鈥檛 have the implication that it should,鈥 he added.

One patient, for example, for years resisted entreaties from his wife, a nurse, to 鈥渟ee someone鈥 about his visibly rounded upper back.

Bob Grossman, 74, a retired public school teacher in Portland, blamed poor posture instead and told himself to straighten up. 鈥淚 thought, 鈥業t can鈥檛 be osteoporosis 鈥 I鈥檓 a guy,鈥欌 he said. But it was.

Another obstacle to screening: 鈥淐linical practice guidelines are all over the place,鈥 Col贸n-Emeric said.

Professional associations like the Endocrine Society and the American Society for Bone and Mineral Research recommend that men 50 and older who have a risk factor, and all men over 70, .

But the and the have deemed the evidence for screening of men 鈥渋nsufficient.鈥 Clinical trials have found that osteoporosis , as in women, but most male studies have been too small or lacked enough follow-up to show whether fractures also declined.

The task force鈥檚 position means that Medicare and many private insurers generally won鈥檛 cover screening for men who haven鈥檛 had a fracture, though they will cover care for men diagnosed with osteoporosis.

鈥淭hings have been stalled for decades,鈥 Orwoll said.

So it may fall to older men themselves to ask their doctors about a DXA (pronounced DECKS-ah) scan, widely available at $100 to $300 out-of-pocket. Otherwise, because osteoporosis is typically asymptomatic, men (and women, who are also undertested and undertreated) don鈥檛 know their bones have deteriorated until one breaks.

鈥淚f you had a fracture after age 50, you should have a bone scan 鈥 that鈥檚 one of the key indicators,鈥 Orwoll advised.

Other risk factors: falls, a family history of hip fractures, and a fairly long list of other health conditions including rheumatoid arthritis, hyperthyroidism and Parkinson鈥檚 disease. Smoking and excessive alcohol use increase the odds of osteoporosis as well.

鈥淎 number of medications also do a number on your bone density,鈥 Col贸n-Emeric added, notably steroids and prostate cancer drugs.

When a scan reveals osteoporosis, depending on its severity, doctors may prescribe oral medications like Fosamax or Actonel, intravenous formulations like Reclast, daily self-injections of Forteo or Tymlos, or twice-annual injections of Prolia.

Lifestyle changes like exercising, taking calcium and vitamin D supplements, stopping smoking, and drinking only moderately will help but aren鈥檛 sufficient to stop or reverse bone loss, Col贸n-Emeric said.

Although guidelines don鈥檛 universally recommend it, at least not yet, she would like to see all men age 70 and up be screened, because the odds of disability after hip fractures are so high 鈥 two-thirds of older people will not regain their prior mobility, she noted 鈥 and the medications that treat it are effective and often inexpensive.

But that osteoporosis threatens men, too, has progressed 鈥渁t a snail鈥檚 pace,鈥 Orwoll said.

Klein remembers attending a seminar to instruct patients like him in using the drug Forteo. 鈥淚 was the only male there,鈥 he said.

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