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The State of Vaccine Supply: 鈥極paque.鈥 Unpredictable. 鈥楬ard to Pin Down.鈥

Even as the pace of vaccination against covid-19 has steadily accelerated 鈥 hitting an average of of January 鈥 the frustration felt by many of those unable to secure an appointment hasn鈥檛 waned.

Why, they wonder, can鈥檛 I get one if 100 million shots will soon be administered?

Of course, the answers aren鈥檛 simple. Rules keep changing. Data about the number of vaccines delivered and administered 鈥 backed by computer systems that often can鈥檛 efficiently exchange information with one another 鈥 lag. Sign-up systems are clunky and balkanized.

But here鈥檚 the real bottom line: Demand far exceeds supply 鈥 at least for the moment.

Here are four things to know:

1. Many states don鈥檛 know exactly where the doses are, and the feds don鈥檛 either.

According to the Centers for Disease Control and Prevention,of the Moderna and Pfizer-BioNTech vaccines were distributed and 33.9 million administered by the first week in February.

Still, questions swirl around the difference between administered and shipped doses. Some have likely reached people鈥檚 arms, but the record-keeping and reporting from the various medical providers within states can be slow.

In California, where the rollout per capita has trailed other states鈥 progress, frustration with tracking doses 鈥 Blue Shield of California 鈥 , replacing a strategy that relied on multiple agencies, including health departments, health systems, hospitals and the Department of Corrections and Rehabilitation.

Health and policy experts, too, express confusion.

鈥淚t鈥檚 very opaque to many of us,鈥 said Dr. Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security, who is following the rollout closely. 鈥淭he CDC tracker shows how many are distributed and how many are given. Everything else is ephemeral and hard to pin down.鈥

For example, Biden administration officials have maintained that they hold a two- to three-day supply in reserve, but Adalja said it isn鈥檛 clear how many doses that represents.

The administration plans to increase shipments to states for a few weeks in February . But medical providers still may not know from week to week how much they will receive from the state.

鈥淭here鈥檚 a lot of unpredictability,鈥 Adalja said. 鈥淵ou can鈥檛 track the vaccine the way you track an Amazon package. I have a colleague who works with hospitals taking deliveries and they themselves are not understanding when they will get vaccine.鈥

Despite the problems, the U.S. has vaccinated just over 8.2% of the population, putting it about sixth in the world, . And, according to a report, more people in the U.S. had received at least one of the two-shot regimen by early February 鈥 33.9 million 鈥 than the number of reported cases, 26.3 million, although that number is likely an undercount.

鈥淭he percentage of the population vaccinated in a relatively short period is pretty good,鈥 said Dr. Marcus Plescia, chief medical officer for the Association of State and Territorial Health Officials.

The main concern, he added, is the difference between shipped amounts and administered dose: 鈥淭hat鈥檚 where there鈥檚 some controversy.鈥

He suspects much of the discrepancy involves delays in entering information into state vaccine data systems, 鈥渨hich are pretty challenged and haven鈥檛 been invested in in decades."

2. Simple math signaled the first few phases would quickly exceed available doses.

After deliberating on the fastest way to roll out the vaccines 鈥 and trying to foster equity among groups 鈥 the Advisory Committee on Immunization Practices issued a report in late December recommending to the CDC guidelines on prioritizing people.

The first group, called 鈥1a,鈥 should include front-line health care workers and residents and staff members in long-term care facilities, totaling an , the committee said. Those vaccinations began in December, when Pfizer and Moderna were set to , or enough of the two-dose regimen for 22.5 million people.

Next in line: those who deal with the public in essential jobs, such as first responders, grocery clerks and educators, as well as people age 75 and up.

That 鈥1b鈥 group, when added to the first, brought the total potential number of people eligible for vaccination to 73 million.

Those numbers exceeded the approximately 120 million doses that Pfizer and Moderna had contracted to deliver by the end of March, which was enough for 60 million people. So, even with reported vaccine hesitancy among some groups, it was clear at the start that supplies would be limited into the spring.

Of course, states did not have to follow the recommendations. And many did not.

Some states moved early to expand priority to people 65 and older. There are an estimated 53 million in that group, according to the advisory committee, although some may have overlapped with the first phase.

One of the first states to loosen eligibility was Florida, where Republican Gov. Ron DeSantis in late December said he , and moved essential workers, such as grocery clerks, further down in the rollout. Long lines immediately formed, with seniors sometimes waiting overnight in front of health care facilities in hopes of getting a shot.

鈥淥nce you tell everyone over 65 they can get it, it鈥檚 difficult to take that back,鈥 said Plescia. 鈥淏ut it got their hopes up and they think it鈥檚 just a matter of perseverance. The fact is, there isn鈥檛 enough vaccine to do it and won鈥檛 be for at least several more weeks.鈥

3. The problem grew in the waning days of the Trump administration.

Further complicating the situation, in January the outgoing Trump administration urged states to consider expanding eligibility to all people 65 and older.

鈥淚t鈥檚 simply much easier to manage allocating vaccines and appointments to everyone 65 and over rather than narrower, more complex categories,鈥 Alex Azar, then-secretary of Health and Human Services, said

At the time, the administration had contracts in place to buy 400 million doses, following a Dec. 23 decision to buy an additional 200 million doses from Moderna . The contract called for delivery by the end of June or July.

Azar鈥檚 comments played into an ongoing debate in public health circles between those who advocated strictly following the rollout guidelines to try to maintain equity while balancing limited supplies, and others who said it was important to vaccinate as many people as possible, as quickly as possible, even if that meant changing the guidelines.

Don鈥檛 wait, Azar urged states, for everyone in group 1a to be vaccinated before moving on to the next group. And, he added, 鈥渨e鈥檙e now making the full reserve of doses we have available for order.鈥

But, as it turned out, the Trump administration had already distributed its reserve supply 鈥 and .

鈥淪ome states stayed the course as far as their original priority groups, but others instantly opened up to be consistent with federal guidelines,鈥 said Katie Greene, a visiting policy associate at the Duke-Margolis Center for Health Policy and that outlined the CDC鈥檚 guidance on vaccine rollout. 鈥淚n some ways, it has helped speed up vaccinations. In other respects, there鈥檚 a fundamental limit to the number of vaccines available.鈥

Going to over-65 eligibility 鈥渨asn鈥檛 a mistake,鈥 if regions were delaying vaccinations while waiting for those in the first groups to overcome hesitancy about getting the shots, said Adalja. In some cases, 鈥渢he initial groups were an obstacle for getting vaccines into arms.鈥

Yet some experts said the move falsely hyped people鈥檚 expectations of when they would get the vaccine.

Revising the priority groups potentially furthered inequity in distribution, benefiting those best able to work the internet, or their connections, or those who could drive long distances to mass vaccination centers. Many vulnerable people who are older, poorer, in worse health or in public-facing jobs with little time off now had to compete with a far larger group of eligible folks when trying to get in line.

鈥淭he politics have trumped science,鈥 said Scott Ratzan, a distinguished lecturer at the City University of New York graduate school of public health. 鈥淲e started with Florida lowering to 65 as fast as it could, which had to do with the politics of who the voters are. Now Florida cannot match the demand for vaccines with either the supply or the need.鈥

4. Help is on the way, but patience is required.

Although vaccine supply is limited now 鈥 and likely will be for weeks 鈥 good news is on the horizon.

Pfizer and to deliver about 200 million doses by the end of March, .

Between them, another 200 million doses are expected to be fully delivered by July, under the December purchase by the Trump administration. Pfizer recently told investors it was on track to deliver its doses by the end of May, , mainly because an additional dose of vaccine can be extracted from each vial with special syringes.

Finally, Biden administration officials said in late January they are close to a deal to purchase another 200 million doses from the two manufacturers, although a final agreement has not been announced. If it goes through, the U.S. will receive 600 million doses in all this year from the two manufacturers, enough for 300 million residents.

And there is likely another vaccine in the wings. Johnson & Johnson on Thursday the Food and Drug Administration for emergency use authorization for its vaccine and said it to the U.S. by the end of June. That鈥檚 enough of the one-shot product for 100 million people.

鈥淲e won鈥檛 see the impact until spring and summer. Right now, the supply is where it is,鈥 said Adalja at Johns Hopkins. 鈥淭hese bigger amounts will get us over the hump of getting eligible populations vaccinated. It鈥檚 clear to everyone that vaccination will continue through the summer.鈥

Patience will be key, said Plescia at the state health officers association: 鈥淲e鈥檝e got to readjust people鈥檚 expectations. The public is not going to get vaccinated for a while. Even for people over 65, it will be a little while.鈥

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