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Can certain medications increase your risk of dementia? A new study suggests that people who take a class of common medicines called anticholinergic drugs for several years may be more likely to develop dementia as they age. This is not a new hypothesis about these drugs, which are used to treat a wide range of conditions from depression to epilepsy to incontinence. (Belluck, 6/25)

Researchers wrote in the study that "there was nearly a 50% increased odds of dementia" associated with a total anticholinergic exposure of more than 1,095 daily doses within a 10-year period, which is equivalent to an older adult taking a strong anticholinergic medication daily for at least three years, compared with no exposure. "The study is important because it strengthens a growing body of evidence showing that strong anticholinergic drugs have long term associations with dementia risk," said Carol Coupland, professor of medical statistics in primary care at the University of Nottingham in the United Kingdom and first author of the study. (Howard, 6/25)

After analyzing the results, they found those on anticholinergic medications had almost a 50% increased chance of developing dementia, compared to those who didn’t have prescriptions for anticholinergic drugs. The risk was only associated with 1,095 daily doses within a 10-year period, which is equivalent to an older adult taking a strong anticholinergic medication daily for at least three years. (Parker, 6/25)

The researchers found no significant increases in dementia risk associated with antihistamines, skeletal muscle relaxants, gastrointestinal antispasmodics, antiarrhythmics, or antimuscarinic bronchodilators, but associations were found among other classes of anticholinergic drugs. An estimated 47 million people worldwide were living with dementia in 2015, while in the United States around 5.7 million people have Alzheimer dementia, according to the study. (Aspegren, 6/24)